PPFIA4 [The Human Chemical-Genetic Interaction Map Project]

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======= PPFIA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPFIA4
  * **<color #00a2e8>Official Name</color>**: PTPRF interacting protein alpha 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8497|8497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75335|O75335]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPFIA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPFIA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603145|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate secretion|
|presynaptic active zone|
|acidic amino acid transport|
|dicarboxylic acid transport|
|acid secretion|
|signal release from synapse|
|neurotransmitter secretion|
|amino acid transport|
|signal release|
|neurotransmitter transport|
|synapse|
|carboxylic acid transport|
|organic acid transport|
|regulation of neurotransmitter levels|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|anion transport|
|cell surface|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|ion transport|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.553|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.552|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.55|
|[[:human genes:t:tfip11|TFIP11]]|0.536|
|[[:human genes:n:nupl1|NUPL1]]|0.503|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.498|
|[[:human genes:r:rps28|RPS28]]|0.497|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.495|
|[[:human genes:r:rps12|RPS12]]|0.489|
|[[:human genes:t:tceb3c|TCEB3C]]|0.476|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.472|
|[[:human genes:i:ik|IK]]|0.471|
|[[:human genes:a:akirin2|AKIRIN2]]|0.466|
|[[:human genes:h:hivep3|HIVEP3]]|0.461|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.46|
|[[:human genes:r:rpl35|RPL35]]|0.458|
|[[:human genes:o:orc6|ORC6]]|0.455|
|[[:human genes:r:rps2|RPS2]]|0.45|
|[[:human genes:p:psmb2|PSMB2]]|0.447|
|[[:human genes:n:nup85|NUP85]]|0.446|
|[[:human genes:a:aamp|AAMP]]|0.444|
|[[:human genes:z:znf830|ZNF830]]|0.444|
|[[:human genes:c:ckap5|CKAP5]]|0.444|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.443|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.442|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.442|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.442|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.441|
|[[:human genes:n:nup133|NUP133]]|0.441|
|[[:human genes:c:cdc73|CDC73]]|0.437|
|[[:human genes:p:psmc6|PSMC6]]|0.437|
|[[:human genes:r:rps9|RPS9]]|0.437|
|[[:human genes:v:vasn|VASN]]|0.436|
|[[:human genes:d:ddtl|DDTL]]|0.435|
|[[:human genes:p:pola2|POLA2]]|0.432|
|[[:human genes:c:cdca3|CDCA3]]|0.431|
|[[:human genes:x:xylt2|XYLT2]]|0.43|
|[[:human genes:a:ankle2|ANKLE2]]|0.43|
|[[:human genes:p:psma6|PSMA6]]|0.429|
|[[:human genes:d:dock6|DOCK6]]|0.429|
|[[:human genes:c:cenpp|CENPP]]|0.428|
|[[:human genes:k:krt78|KRT78]]|0.428|
|[[:human genes:t:ticrr|TICRR]]|0.428|
|[[:human genes:s:snrpa1|SNRPA1]]|0.424|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.423|
|[[:human genes:h:hap1|HAP1]]|0.423|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.422|
|[[:human genes:s:s1pr4|S1PR4]]|0.422|
|[[:human genes:c:c14orf93|C14orf93]]|0.42|
|[[:human genes:p:pole|POLE]]|0.42|
|[[:human genes:n:ndc1|NDC1]]|0.42|
|[[:human genes:c:chd4|CHD4]]|0.419|
|[[:human genes:n:narfl|NARFL]]|0.418|
|[[:human genes:c:cbwd5|CBWD5]]|0.417|
|[[:human genes:f:fcn2|FCN2]]|0.415|
|[[:human genes:c:cbwd3|CBWD3]]|0.415|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.413|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.413|
|[[:human genes:s:sf3a1|SF3A1]]|0.41|
|[[:human genes:n:ndc80|NDC80]]|0.409|
|[[:human genes:c:cope|COPE]]|0.409|
|[[:human genes:n:nop16|NOP16]]|0.408|
|[[:human genes:n:naaladl1|NAALADL1]]|0.407|
|[[:human genes:p:psmd1|PSMD1]]|0.406|
|[[:human genes:m:mt1e|MT1E]]|0.406|
|[[:human genes:c:chaf1a|CHAF1A]]|0.405|
|[[:human genes:l:lrr1|LRR1]]|0.405|
|[[:human genes:r:rad21|RAD21]]|0.405|
|[[:human genes:l:lad1|LAD1]]|0.404|
|[[:human genes:c:cdc6|CDC6]]|0.403|
|[[:human genes:s:supt5h|SUPT5H]]|0.403|
|[[:human genes:s:syt9|SYT9]]|0.403|
|[[:human genes:s:scaf1|SCAF1]]|0.402|
|[[:human genes:k:kctd17|KCTD17]]|0.402|
|[[:human genes:t:ttyh1|TTYH1]]|0.401|
|[[:human genes:t:twistnb|TWISTNB]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPFIA4 Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>