PPHLN1 [The Human Chemical-Genetic Interaction Map Project]

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======= PPHLN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPHLN1
  * **<color #00a2e8>Official Name</color>**: periphilin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51535|51535]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEY8|Q8NEY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPHLN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPHLN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lge1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to heterochromatin|
|positive regulation of methylation-dependent chromatin silencing|
|regulation of methylation-dependent chromatin silencing|
|positive regulation of chromatin silencing|
|protein localization to chromatin|
|regulation of chromatin silencing|
|protein localization to chromosome|
|negative regulation of gene expression, epigenetic|
|positive regulation of chromatin organization|
|chromosome|
|regulation of gene silencing|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|keratinization|
|regulation of gene expression, epigenetic|
|keratinocyte differentiation|
|epidermal cell differentiation|
|regulation of chromosome organization|
|skin development|
|epidermis development|
|positive regulation of organelle organization|
|epithelial cell differentiation|
|protein localization to organelle|
|Golgi apparatus|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of gene expression|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.6|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.57|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.5|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.17|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.12|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.03|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.98|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.98|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.96|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.95|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.95|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.9|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.89|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.88|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.87|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.85|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.75|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.85|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.89|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mphosph8|MPHOSPH8]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPHLN1 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>