PPIB [The Human Chemical-Genetic Interaction Map Project]

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======= PPIB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIB
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5479|5479]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23284|P23284]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123841|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of post-translational protein modification|
|positive regulation by host of viral genome replication|
|endoplasmic reticulum chaperone complex|
|modulation by host of viral genome replication|
|RNA polymerase binding|
|positive regulation by host of viral process|
|cyclosporin A binding|
|smooth endoplasmic reticulum|
|modulation by host of viral process|
|positive regulation of multicellular organism growth|
|positive regulation of viral genome replication|
|protein refolding|
|protein peptidyl-prolyl isomerization|
|peptidyl-prolyl cis-trans isomerase activity|
|chaperone-mediated protein folding|
|peptidyl-proline modification|
|positive regulation of viral life cycle|
|collagen binding|
|regulation of multicellular organism growth|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|regulation of viral genome replication|
|melanosome|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|unfolded protein binding|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|positive regulation of developmental growth|
|protein stabilization|
|bone development|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein folding|
|positive regulation of growth|
|regulation of protein stability|
|endoplasmic reticulum lumen|
|regulation of developmental growth|
|focal adhesion|
|skeletal system development|
|positive regulation of multi-organism process|
|protein-containing complex|
|regulation of growth|
|perinuclear region of cytoplasm|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|endoplasmic reticulum|
|positive regulation of developmental process|
|RNA binding|
|positive regulation of multicellular organismal process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4790
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIB Expression in NALM6 Cells: 8.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>