PPIH [The Human Chemical-Genetic Interaction Map Project]

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======= PPIH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIH
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10465|10465]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43447|O43447]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606095|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. {ECO:0000269|PubMed:11823439, ECO:0000269|PubMed:12875835, ECO:0000269|PubMed:9570313}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U4/U6 snRNP|
|cyclosporin A binding|
|ribonucleoprotein complex binding|
|U4/U6 x U5 tri-snRNP complex|
|positive regulation of viral genome replication|
|protein refolding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|peptidyl-proline modification|
|positive regulation of viral life cycle|
|spliceosomal complex|
|regulation of viral genome replication|
|positive regulation of viral process|
|unfolded protein binding|
|regulation of viral life cycle|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein folding|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|angiogenesis|
|RNA splicing|
|nuclear speck|
|blood vessel morphogenesis|
|mRNA processing|
|blood vessel development|
|positive regulation of multi-organism process|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|mRNA metabolic process|
|regulation of multi-organism process|
|tube development|
|circulatory system development|
|RNA processing|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.97|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.99|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.06|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.19|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.5|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c9orf78|C9orf78]]|0.467|
|[[:human genes:w:wbp11|WBP11]]|0.441|
|[[:human genes:d:dazap1|DAZAP1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 66/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|2/28|
|bone|3/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|1/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1372
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIH Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>