PPIL2 [The Human Chemical-Genetic Interaction Map Project]

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======= PPIL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIL2
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23759|23759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13356|Q13356]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607588|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). {ECO:0000250|UniProtKB:Q08752, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000303|PubMed:8660300}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rtf2|
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-ubiquitin ligase activity|
|cyclosporin A binding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|peptidyl-proline modification|
|Golgi lumen|
|protein localization to plasma membrane|
|ubiquitin protein ligase activity|
|protein localization to cell periphery|
|protein folding|
|protein polyubiquitination|
|leukocyte migration|
|protein localization to membrane|
|protein ubiquitination|
|protein modification by small protein conjugation|
|peptidyl-amino acid modification|
|cell migration|
|protein modification by small protein conjugation or removal|
|localization of cell|
|cell motility|
|locomotion|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.27|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.16|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.05|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.91|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 89/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|5/26|
|breast|8/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|5/21|
|liver|0/20|
|lung|8/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|5/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 866
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIL2 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>