PPP1CA [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PPP1CA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1CA
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 catalytic subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5499|5499]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62136|P62136]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1CA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1CA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176875|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5- ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). {ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of translational initiation by eIF2 alpha dephosphorylation|
|regulation of glycogen catabolic process|
|PTW/PP1 phosphatase complex|
|glycogen granule|
|protein phosphatase type 1 complex|
|regulation of cellular carbohydrate catabolic process|
|regulation of translational initiation in response to stress|
|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|peptidyl-serine dephosphorylation|
|peptidyl-threonine dephosphorylation|
|regulation of translation in response to stress|
|cadherin binding involved in cell-cell adhesion|
|protein phosphatase 1 binding|
|entrainment of circadian clock by photoperiod|
|beta-catenin destruction complex disassembly|
|response to lead ion|
|photoperiodism|
|entrainment of circadian clock|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|ribonucleoprotein complex binding|
|regulation of glycogen metabolic process|
|regulation of polysaccharide biosynthetic process|
|phosphoprotein phosphatase activity|
|regulation of polysaccharide metabolic process|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|phosphatase activity|
|glycogen metabolic process|
|positive regulation of extrinsic apoptotic signaling pathway|
|cellular glucan metabolic process|
|glucan metabolic process|
|circadian regulation of gene expression|
|energy reserve metabolic process|
|protein serine/threonine phosphatase activity|
|cellular polysaccharide metabolic process|
|regulation of translational initiation|
|polysaccharide metabolic process|
|regulation of carbohydrate catabolic process|
|canonical Wnt signaling pathway|
|regulation of carbohydrate biosynthetic process|
|presynapse|
|negative regulation of protein binding|
|cell-cell adherens junction|
|nuclear chromosome, telomeric region|
|regulation of glucose metabolic process|
|regulation of circadian rhythm|
|branching morphogenesis of an epithelial tube|
|perikaryon|
|regulation of cellular carbohydrate metabolic process|
|circadian rhythm|
|dendritic spine|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of generation of precursor metabolites and energy|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|cellular carbohydrate metabolic process|
|negative regulation of binding|
|respiratory tube development|
|positive regulation of apoptotic signaling pathway|
|respiratory system development|
|regulation of carbohydrate metabolic process|
|protein dephosphorylation|
|regulation of protein binding|
|energy derivation by oxidation of organic compounds|
|protein-containing complex disassembly|
|rhythmic process|
|regulation of canonical Wnt signaling pathway|
|epithelial tube morphogenesis|
|response to light stimulus|
|dephosphorylation|
|glutamatergic synapse|
|regulation of translation|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|response to metal ion|
|regulation of binding|
|regulation of cellular component size|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|generation of precursor metabolites and energy|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|morphogenesis of an epithelium|
|response to radiation|
|carbohydrate metabolic process|
|cell division|
|cell-cell adhesion|
|regulation of anatomical structure size|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|tissue morphogenesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of cell death|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|nucleolus|
|cell adhesion|
|biological adhesion|
|oxidation-reduction process|
|regulation of catabolic process|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.55|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.09|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.97|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.96|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.89|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.83|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.73|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.7|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.98|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.25|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.6|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.6|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.88|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp1cc|PPP1CC]]|0.558|
|[[:human genes:p:ppp1r2|PPP1R2]]|0.469|
|[[:human genes:a:atat1|ATAT1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 39/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|1/25|
|breast|2/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|2/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9317
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1CA Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>