PPP1R15B [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R15B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R15B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 15B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84919|84919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SWA1|Q5SWA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R15B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R15B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613257|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269|PubMed:26159176, ECO:0000269|PubMed:26307080}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP1c bdg|
|CReP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|
|negative regulation of PERK-mediated unfolded protein response|
|protein phosphatase type 1 complex|
|regulation of PERK-mediated unfolded protein response|
|negative regulation of endoplasmic reticulum unfolded protein response|
|ER overload response|
|peptidyl-serine dephosphorylation|
|positive regulation of phosphoprotein phosphatase activity|
|regulation of endoplasmic reticulum unfolded protein response|
|protein phosphatase regulator activity|
|positive regulation of phosphatase activity|
|ER-nucleus signaling pathway|
|negative regulation of response to endoplasmic reticulum stress|
|positive regulation of protein dephosphorylation|
|positive regulation of dephosphorylation|
|regulation of translational initiation|
|regulation of response to endoplasmic reticulum stress|
|regulation of phosphoprotein phosphatase activity|
|response to hydrogen peroxide|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|response to reactive oxygen species|
|regulation of dephosphorylation|
|protein dephosphorylation|
|cellular response to biotic stimulus|
|response to endoplasmic reticulum stress|
|response to antibiotic|
|dephosphorylation|
|regulation of translation|
|response to oxidative stress|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|response to toxic substance|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of cellular response to stress|
|positive regulation of hydrolase activity|
|endoplasmic reticulum|
|response to drug|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.76|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.82|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.1|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.14|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnajc16|DNAJC16]]|0.502|
|[[:human genes:e:eif2b4|EIF2B4]]|0.477|
|[[:human genes:o:ogfr|OGFR]]|0.424|
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.413|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.407|
|[[:human genes:e:eif2b5|EIF2B5]]|0.401|
|[[:human genes:c:chchd3|CHCHD3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 256/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|7/28|
|bone|9/26|
|breast|14/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|11/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|7/20|
|lung|35/75|
|lymphocyte|6/16|
|ovary|12/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1002
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R15B Expression in NALM6 Cells: 8.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>