PPP2CA [The Human Chemical-Genetic Interaction Map Project]

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======= PPP2CA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP2CA
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 catalytic subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5515|5515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P67775|P67775]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2CA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2CA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176915|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. {ECO:0000250, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:9920888}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule binding|
|mitotic nuclear envelope reassembly|
|regulation of microtubule binding|
|negative regulation of tyrosine phosphorylation of STAT protein|
|peptidyl-serine dephosphorylation|
|peptidyl-threonine dephosphorylation|
|GABA receptor binding|
|nuclear envelope reassembly|
|protein phosphatase type 2A complex|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|response to lead ion|
|negative regulation of epithelial to mesenchymal transition|
|inactivation of MAPK activity|
|phosphoprotein phosphatase activity|
|tau protein binding|
|negative regulation of peptidyl-tyrosine phosphorylation|
|nuclear envelope organization|
|chromosome, centromeric region|
|protein serine/threonine phosphatase activity|
|negative regulation of MAP kinase activity|
|regulation of tyrosine phosphorylation of STAT protein|
|ceramide metabolic process|
|regulation of epithelial to mesenchymal transition|
|positive regulation of protein binding|
|regulation of DNA replication|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|spindle pole|
|mesoderm development|
|regulation of receptor signaling pathway via JAK-STAT|
|nucleus organization|
|negative regulation of protein serine/threonine kinase activity|
|regulation of receptor signaling pathway via STAT|
|microtubule cytoskeleton|
|sphingolipid metabolic process|
|negative regulation of MAPK cascade|
|positive regulation of binding|
|negative regulation of cell growth|
|protein C-terminus binding|
|nuclear-transcribed mRNA catabolic process|
|membrane lipid metabolic process|
|protein dephosphorylation|
|mRNA catabolic process|
|regulation of protein binding|
|meiotic cell cycle|
|negative regulation of protein kinase activity|
|membrane raft|
|negative regulation of growth|
|negative regulation of kinase activity|
|RNA catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|synapse|
|negative regulation of transferase activity|
|dephosphorylation|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of Wnt signaling pathway|
|response to metal ion|
|nucleobase-containing compound catabolic process|
|regulation of binding|
|RNA splicing|
|negative regulation of protein phosphorylation|
|regulation of cell growth|
|endomembrane system organization|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|negative regulation of phosphorylation|
|organic cyclic compound catabolic process|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|positive regulation of transferase activity|
|regulation of growth|
|regulation of cell adhesion|
|mitotic cell cycle|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|regulation of MAPK cascade|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|membrane organization|
|regulation of kinase activity|
|RNA processing|
|cellular macromolecule catabolic process|
|apoptotic process|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|RNA metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.67|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.59|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.33|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.28|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.23|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.11|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.06|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.02|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.99|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.85|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.85|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.8|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.8|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.78|
|[[:results:exp539|42°C R08 exp539]]|-1.76|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.75|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.73|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.22|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.31|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 466/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|19/28|
|bone|13/26|
|breast|24/33|
|central nervous system|31/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|10/21|
|liver|9/20|
|lung|45/75|
|lymphocyte|14/16|
|ovary|15/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|22/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 432
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2CA Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>