PPP2R5A [The Human Chemical-Genetic Interaction Map Project]

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======= PPP2R5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP2R5A
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 regulatory subunit B'alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5525|5525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15172|Q15172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2R5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2R5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601643|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|B56|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lipid kinase activity|
|protein phosphatase activator activity|
|protein phosphatase type 2A complex|
|negative regulation of protein localization to plasma membrane|
|negative regulation of protein localization to cell periphery|
|M band|
|negative regulation of protein localization to membrane|
|protein phosphatase regulator activity|
|phosphoprotein phosphatase activity|
|positive regulation of protein dephosphorylation|
|regulation of protein autophosphorylation|
|chromosome, centromeric region|
|positive regulation of dephosphorylation|
|regulation of lipid kinase activity|
|negative regulation of lipid metabolic process|
|kinase binding|
|regulation of protein localization to plasma membrane|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|regulation of phosphoprotein phosphatase activity|
|Z disc|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|regulation of protein localization to membrane|
|regulation of dephosphorylation|
|protein dephosphorylation|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|dephosphorylation|
|regulation of lipid metabolic process|
|negative regulation of phosphorylation|
|centrosome|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of catalytic activity|
|regulation of kinase activity|
|regulation of cellular localization|
|regulation of transferase activity|
|regulation of protein localization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.71|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16995
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2R5A Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>