PPP2R5B [The Human Chemical-Genetic Interaction Map Project]

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======= PPP2R5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP2R5B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 regulatory subunit B'beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5526|5526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15173|Q15173]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2R5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2R5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601644|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As the regulatory component of the serine/threonine- protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|B56|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neurotrophin TRK receptor signaling pathway|
|protein phosphatase activator activity|
|regulation of neurotrophin TRK receptor signaling pathway|
|protein phosphatase type 2A complex|
|protein phosphatase regulator activity|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|negative regulation of protein kinase B signaling|
|regulation of protein autophosphorylation|
|IRE1-mediated unfolded protein response|
|positive regulation of cell cycle arrest|
|endoplasmic reticulum unfolded protein response|
|regulation of cell cycle arrest|
|regulation of phosphoprotein phosphatase activity|
|regulation of phosphatidylinositol 3-kinase signaling|
|cellular response to unfolded protein|
|regulation of protein dephosphorylation|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|regulation of signaling receptor activity|
|regulation of phosphatase activity|
|response to topologically incorrect protein|
|regulation of dephosphorylation|
|protein dephosphorylation|
|regulation of protein kinase B signaling|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|response to endoplasmic reticulum stress|
|positive regulation of DNA-binding transcription factor activity|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|positive regulation of cell cycle process|
|dephosphorylation|
|negative regulation of cell cycle process|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|positive regulation of cell projection organization|
|regulation of DNA-binding transcription factor activity|
|regulation of protein complex assembly|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|negative regulation of cell cycle|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.76|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2R5B Expression in NALM6 Cells: 2.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>