PPP6R3 [The Human Chemical-Genetic Interaction Map Project]

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======= PPP6R3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP6R3
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 6 regulatory subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55291|55291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5H9R7|Q5H9R7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP6R3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP6R3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|protein phosphatase binding|
|vesicle targeting|
|vesicle budding from membrane|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|establishment of vesicle localization|
|regulation of phosphatase activity|
|vesicle localization|
|regulation of dephosphorylation|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|organelle localization|
|Golgi membrane|
|membrane organization|
|regulation of hydrolase activity|
|intracellular transport|
|protein-containing complex assembly|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.95|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.76|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.72|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.71|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.79|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.8|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.92|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.97|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.09|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.18|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.05|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|3.07|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.12|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.49|
|[[:human genes:p:ppp2r4|PPP2R4]]|0.464|
|[[:human genes:t:tiprl|TIPRL]]|0.448|
|[[:human genes:c:cyb5r4|CYB5R4]]|0.419|
|[[:human genes:u:ubald2|UBALD2]]|0.413|
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3435
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP6R3 Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>