PPT1 [The Human Chemical-Genetic Interaction Map Project]

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======= PPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPT1
  * **<color #00a2e8>Official Name</color>**: palmitoyl-protein thioesterase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5538|5538]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50897|P50897]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600722|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748). {ECO:0000269|PubMed:8816748}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Palm thioest|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of pinocytosis|
|lysosomal lumen acidification|
|protein depalmitoylation|
|macromolecule depalmitoylation|
|palmitoyl-(protein) hydrolase activity|
|regulation of pinocytosis|
|pinocytosis|
|regulation of phospholipase A2 activity|
|regulation of lysosomal lumen pH|
|palmitoyl-CoA hydrolase activity|
|grooming behavior|
|lipoprotein catabolic process|
|vacuolar acidification|
|membrane raft organization|
|sphingolipid catabolic process|
|fatty-acyl-CoA biosynthetic process|
|membrane lipid catabolic process|
|fatty-acyl-CoA metabolic process|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|cofactor transport|
|intracellular pH reduction|
|pH reduction|
|positive regulation of receptor-mediated endocytosis|
|lytic vacuole organization|
|lysosome organization|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|protein deacylation|
|macromolecule deacylation|
|regulation of phospholipase activity|
|adult locomotory behavior|
|associative learning|
|regulation of intracellular pH|
|regulation of cellular pH|
|fatty acid derivative biosynthetic process|
|lysosomal lumen|
|thioester metabolic process|
|acyl-CoA metabolic process|
|regulation of lipase activity|
|regulation of pH|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|neurotransmitter secretion|
|signal release from synapse|
|cellular monovalent inorganic cation homeostasis|
|lipoprotein metabolic process|
|synaptic vesicle|
|vacuole organization|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|monovalent inorganic cation homeostasis|
|negative regulation of neuron apoptotic process|
|adult behavior|
|learning|
|purine ribonucleotide biosynthetic process|
|sphingolipid metabolic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|signal release|
|purine-containing compound biosynthetic process|
|neurotransmitter transport|
|sulfur compound biosynthetic process|
|negative regulation of cell growth|
|locomotory behavior|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|regulation of endocytosis|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cofactor biosynthetic process|
|visual perception|
|sensory perception of light stimulus|
|membrane raft|
|regulation of synapse structure or activity|
|receptor-mediated endocytosis|
|negative regulation of growth|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|lysosome|
|learning or memory|
|axon|
|cognition|
|lipid catabolic process|
|regulation of neuron death|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|regulation of neurotransmitter levels|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|neuronal cell body|
|regulation of cell growth|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|synaptic signaling|
|amide biosynthetic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of vesicle-mediated transport|
|endocytosis|
|behavior|
|cellular protein catabolic process|
|carbohydrate derivative biosynthetic process|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|import into cell|
|protein catabolic process|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cellular amide metabolic process|
|neuron development|
|membrane organization|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|cellular lipid metabolic process|
|sensory perception|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|secretion by cell|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|protein transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of cell death|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-3.82|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-3.55|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12864
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPT1 Expression in NALM6 Cells: 7.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>