PRC1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRC1
  * **<color #00a2e8>Official Name</color>**: protein regulator of cytokinesis 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9055|9055]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43663|O43663]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603484|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAP65 ASE1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|contractile ring|
|mitotic spindle elongation|
|spindle elongation|
|spindle microtubule|
|kinesin binding|
|mitotic spindle organization|
|regulation of cytokinesis|
|microtubule bundle formation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|spindle|
|spindle pole|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|midbody|
|regulation of cell division|
|nuclear chromosome segregation|
|microtubule binding|
|chromosome segregation|
|nuclear division|
|organelle fission|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|positive regulation of cell population proliferation|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|cell cycle|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.49|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.35|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.21|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.99|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.88|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.84|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.82|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.8|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.8|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.8|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.74|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.79|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.98|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.28|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.44|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/26|
|breast|28/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 497
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRC1 Expression in NALM6 Cells: 7.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>