PRDX5 [The Human Chemical-Genetic Interaction Map Project]

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======= PRDX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDX5
  * **<color #00a2e8>Official Name</color>**: peroxiredoxin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25824|25824]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30044|P30044]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606583|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Redoxin|
|AhpC-TSA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of transcription by RNA polymerase III|
|RNA polymerase III regulatory region DNA binding|
|thioredoxin peroxidase activity|
|regulation of transcription by RNA polymerase III|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|hydrogen peroxide catabolic process|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|peroxisomal matrix|
|antibiotic catabolic process|
|cofactor catabolic process|
|cell redox homeostasis|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular oxidant detoxification|
|negative regulation of cysteine-type endopeptidase activity|
|cellular detoxification|
|antibiotic metabolic process|
|peroxisome|
|reactive oxygen species metabolic process|
|detoxification|
|cellular response to reactive oxygen species|
|drug catabolic process|
|protein dimerization activity|
|response to reactive oxygen species|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|cytoplasmic vesicle|
|negative regulation of peptidase activity|
|negative regulation of proteolysis|
|mitochondrial matrix|
|response to oxidative stress|
|regulation of endopeptidase activity|
|cofactor metabolic process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|inflammatory response|
|drug metabolic process|
|response to toxic substance|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|apoptotic process|
|oxidation-reduction process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.482|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15488
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDX5 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>