PREB [The Human Chemical-Genetic Interaction Map Project]

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======= PREB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PREB
  * **<color #00a2e8>Official Name</color>**: prolactin regulatory element binding
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10113|10113]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCU5|Q9HCU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PREB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PREB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606395|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. {ECO:0000250|UniProtKB:Q9WTV0, ECO:0000250|UniProtKB:Q9WUQ2}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Sar guanyl-nucleotide exchange factor activity|
|regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis|
|regulation of COPII vesicle coating|
|regulation of vesicle targeting, to, from or within Golgi|
|regulation of ER to Golgi vesicle-mediated transport|
|protein exit from endoplasmic reticulum|
|endoplasmic reticulum exit site|
|GTPase binding|
|IRE1-mediated unfolded protein response|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|guanyl-nucleotide exchange factor activity|
|endoplasmic reticulum unfolded protein response|
|integral component of endoplasmic reticulum membrane|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|protein secretion|
|establishment of protein localization to extracellular region|
|response to unfolded protein|
|protein localization to extracellular region|
|peptide secretion|
|establishment of vesicle localization|
|vesicle localization|
|response to topologically incorrect protein|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|response to endoplasmic reticulum stress|
|GTPase activator activity|
|vesicle organization|
|regulation of intracellular transport|
|establishment of organelle localization|
|Golgi vesicle transport|
|positive regulation of GTPase activity|
|regulation of protein complex assembly|
|regulation of GTPase activity|
|regulation of vesicle-mediated transport|
|organelle localization|
|Golgi membrane|
|positive regulation of hydrolase activity|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|secretion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|DNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.25|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.87|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.79|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 158/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|5/28|
|bone|10/26|
|breast|6/33|
|central nervous system|25/56|
|cervix|2/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|6/21|
|liver|4/20|
|lung|15/75|
|lymphocyte|3/16|
|ovary|6/26|
|pancreas|0/24|
|peripheral nervous system|5/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1072
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PREB Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>