PRICKLE1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRICKLE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRICKLE1
  * **<color #00a2e8>Official Name</color>**: prickle planar cell polarity protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=144165|144165]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MT3|Q96MT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRICKLE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRICKLE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|PET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cardiac muscle cell myoblast differentiation|
|negative regulation of cardiac muscle cell myoblast differentiation|
|negative regulation of cardioblast differentiation|
|regulation of cardioblast differentiation|
|negative regulation of stem cell differentiation|
|negative regulation of cardiocyte differentiation|
|negative regulation of myoblast differentiation|
|coronary vasculature development|
|regulation of cardiocyte differentiation|
|aorta development|
|regulation of myoblast differentiation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|artery development|
|neural tube closure|
|tube closure|
|protein import into nucleus|
|Wnt signaling pathway, planar cell polarity pathway|
|primary neural tube formation|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|neural tube formation|
|regulation of establishment of planar polarity|
|import into nucleus|
|positive regulation of protein ubiquitination|
|regulation of stem cell differentiation|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|embryonic epithelial tube formation|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|protein import|
|morphogenesis of embryonic epithelium|
|tube formation|
|regulation of ubiquitin-dependent protein catabolic process|
|neural tube development|
|protein localization to nucleus|
|negative regulation of canonical Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|nuclear membrane|
|regulation of cellular protein catabolic process|
|regulation of animal organ morphogenesis|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of canonical Wnt signaling pathway|
|epithelial tube morphogenesis|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|positive regulation of catabolic process|
|establishment of protein localization to organelle|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|embryo development|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.33|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.84|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.7|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.71|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.72|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.73|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.73|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.74|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.84|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.98|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.1|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16463
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRICKLE1 Expression in NALM6 Cells: 1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>