PRKACB [The Human Chemical-Genetic Interaction Map Project]

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======= PRKACB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKACB
  * **<color #00a2e8>Official Name</color>**: protein kinase cAMP-activated catalytic subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5567|5567]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22694|P22694]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKACB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKACB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to clozapine|
|response to antipsychotic drug|
|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|cAMP-dependent protein kinase activity|
|cAMP-dependent protein kinase complex|
|protein kinase A signaling|
|high-density lipoprotein particle assembly|
|negative regulation of meiotic cell cycle|
|activation of protein kinase A activity|
|protein kinase A regulatory subunit binding|
|negative regulation of embryonic development|
|plasma lipoprotein particle assembly|
|cellular response to glucagon stimulus|
|protein-lipid complex assembly|
|negative regulation of smoothened signaling pathway|
|renal water homeostasis|
|ciliary base|
|response to glucagon|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|regulation of meiotic cell cycle|
|negative regulation of reproductive process|
|intercellular bridge|
|regulation of protein processing|
|multicellular organismal water homeostasis|
|regulation of protein maturation|
|regulation of plasma lipoprotein particle levels|
|water homeostasis|
|regulation of smoothened signaling pathway|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|renal system process|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|regulation of reproductive process|
|peptidyl-serine phosphorylation|
|peptidyl-serine modification|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|magnesium ion binding|
|innate immune response-activating signal transduction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|activation of innate immune response|
|cellular response to peptide hormone stimulus|
|ubiquitin protein ligase binding|
|blood coagulation|
|coagulation|
|hemostasis|
|response to xenobiotic stimulus|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|multicellular organismal homeostasis|
|cellular response to peptide|
|activation of protein kinase activity|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|extracellular structure organization|
|response to peptide hormone|
|morphogenesis of an epithelium|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|centrosome|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|immune response-activating signal transduction|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|activation of immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|tube development|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|negative regulation of developmental process|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.464|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18514
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKACB Expression in NALM6 Cells: 2.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>