PRKACG [The Human Chemical-Genetic Interaction Map Project]

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======= PRKACG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKACG
  * **<color #00a2e8>Official Name</color>**: protein kinase cAMP-activated catalytic subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5568|5568]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22612|P22612]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKACG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKACG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176893|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cAMP-dependent protein kinase activity|
|high-density lipoprotein particle assembly|
|protein kinase A signaling|
|cAMP-dependent protein kinase complex|
|activation of protein kinase A activity|
|protein kinase A regulatory subunit binding|
|cellular response to glucagon stimulus|
|plasma lipoprotein particle assembly|
|protein-lipid complex assembly|
|ciliary base|
|renal water homeostasis|
|response to glucagon|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|intercellular bridge|
|multicellular organismal water homeostasis|
|regulation of plasma lipoprotein particle levels|
|water homeostasis|
|renal system process|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|peptidyl-serine phosphorylation|
|peptidyl-serine modification|
|gonad development|
|development of primary sexual characteristics|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|blood coagulation|
|coagulation|
|hemostasis|
|multicellular organismal homeostasis|
|cellular response to peptide|
|activation of protein kinase activity|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|extracellular structure organization|
|response to peptide hormone|
|reproductive structure development|
|reproductive system development|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|spermatogenesis|
|immune response-activating signal transduction|
|male gamete generation|
|response to wounding|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|activation of immune response|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|gamete generation|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|response to hormone|
|protein phosphorylation|
|regulation of transferase activity|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.31|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.8|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.71|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKACG Expression in NALM6 Cells: -2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>