PRKAR1B [The Human Chemical-Genetic Interaction Map Project]

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======= PRKAR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKAR1B
  * **<color #00a2e8>Official Name</color>**: protein kinase cAMP-dependent type I regulatory subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5575|5575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31321|P31321]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKAR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKAR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176911|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cNMP binding|
|RIIa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cAMP-dependent protein kinase regulator activity|
|cAMP-dependent protein kinase inhibitor activity|
|negative regulation of cAMP-dependent protein kinase activity|
|protein kinase A catalytic subunit binding|
|cAMP-dependent protein kinase complex|
|regulation of cAMP-dependent protein kinase activity|
|3,5-cyclic-GMP phosphodiesterase activity|
|activation of protein kinase A activity|
|cAMP binding|
|cGMP-mediated signaling|
|cellular response to glucagon stimulus|
|hippocampal mossy fiber to CA3 synapse|
|renal water homeostasis|
|ciliary base|
|response to glucagon|
|multicellular organismal water homeostasis|
|water homeostasis|
|Schaffer collateral - CA1 synapse|
|renal system process|
|regulation of synaptic vesicle cycle|
|negative regulation of protein serine/threonine kinase activity|
|cyclic-nucleotide-mediated signaling|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|learning or memory|
|cellular response to peptide hormone stimulus|
|negative regulation of transferase activity|
|blood coagulation|
|coagulation|
|hemostasis|
|cognition|
|multicellular organismal homeostasis|
|cellular response to peptide|
|activation of protein kinase activity|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|response to peptide hormone|
|negative regulation of protein phosphorylation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|response to peptide|
|wound healing|
|regulation of body fluid levels|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|response to wounding|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|response to hormone|
|regulation of cellular localization|
|protein phosphorylation|
|regulation of transferase activity|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16154
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKAR1B Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>