PRKCI [The Human Chemical-Genetic Interaction Map Project]

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======= PRKCI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKCI
  * **<color #00a2e8>Official Name</color>**: protein kinase C iota
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5584|5584]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41743|P41743]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKCI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKCI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600539|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non- small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. {ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase C|
|C1 1|
|PB1|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of glial cell apoptotic process|
|regulation of glial cell apoptotic process|
|Schmidt-Lanterman incisure|
|positive regulation of glial cell proliferation|
|protein kinase C activity|
|positive regulation of endothelial cell apoptotic process|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|regulation of glial cell proliferation|
|positive regulation of epithelial cell apoptotic process|
|eye photoreceptor cell development|
|bicellular tight junction assembly|
|positive regulation of glucose import|
|tight junction assembly|
|tight junction organization|
|cell leading edge|
|positive regulation of glucose transmembrane transport|
|eye photoreceptor cell differentiation|
|apical junction assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|photoreceptor cell development|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|regulation of endothelial cell apoptotic process|
|positive regulation of Notch signaling pathway|
|positive regulation of protein localization to plasma membrane|
|regulation of glucose import|
|photoreceptor cell differentiation|
|intercellular bridge|
|positive regulation of protein localization to cell periphery|
|positive regulation of gliogenesis|
|regulation of glucose transmembrane transport|
|Golgi vesicle budding|
|regulation of epithelial cell apoptotic process|
|Schaffer collateral - CA1 synapse|
|regulation of protein localization to plasma membrane|
|vesicle budding from membrane|
|regulation of Notch signaling pathway|
|cell-cell junction assembly|
|phospholipid binding|
|regulation of protein localization to cell periphery|
|regulation of gliogenesis|
|establishment of cell polarity|
|positive regulation of protein localization to membrane|
|bicellular tight junction|
|cell-cell junction organization|
|negative regulation of neuron apoptotic process|
|eye morphogenesis|
|microtubule cytoskeleton|
|positive regulation of NF-kappaB transcription factor activity|
|protein targeting to membrane|
|cellular response to insulin stimulus|
|cell junction assembly|
|peptidyl-serine phosphorylation|
|regulation of protein localization to membrane|
|establishment or maintenance of cell polarity|
|peptidyl-serine modification|
|response to interleukin-1|
|positive regulation of transmembrane transport|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cell junction organization|
|response to insulin|
|protein kinase activity|
|actin filament organization|
|sensory organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|establishment of protein localization to membrane|
|cellular response to peptide hormone stimulus|
|endosome|
|positive regulation of neuron projection development|
|vesicle organization|
|regulation of neuron death|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|glutamatergic synapse|
|protein targeting|
|eye development|
|visual system development|
|protein serine/threonine kinase activity|
|sensory system development|
|positive regulation of neuron differentiation|
|Golgi vesicle transport|
|positive regulation of cell projection organization|
|response to peptide hormone|
|regulation of DNA-binding transcription factor activity|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|response to peptide|
|protein localization to membrane|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|sensory organ development|
|regulation of transmembrane transport|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|Golgi membrane|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|neuron development|
|regulation of neurogenesis|
|membrane organization|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|intracellular protein transport|
|response to organonitrogen compound|
|neuron differentiation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|secretion|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKCI Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>