PRKCQ [The Human Chemical-Genetic Interaction Map Project]

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======= PRKCQ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKCQ
  * **<color #00a2e8>Official Name</color>**: protein kinase C theta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5588|5588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04759|Q04759]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKCQ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKCQ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600448|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:8657160}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Pkinase C|
|C1 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of T-helper 2 cell activation|
|regulation of T-helper 2 cell activation|
|positive regulation of T-helper 17 type immune response|
|positive regulation of interleukin-2 biosynthetic process|
|protein kinase C activity|
|positive regulation of telomere capping|
|positive regulation of interleukin-17 production|
|regulation of platelet aggregation|
|negative regulation of T cell apoptotic process|
|regulation of interleukin-2 biosynthetic process|
|regulation of T-helper 17 type immune response|
|membrane protein ectodomain proteolysis|
|positive regulation of interleukin-4 production|
|regulation of homotypic cell-cell adhesion|
|regulation of telomere capping|
|regulation of interleukin-4 production|
|negative regulation of lymphocyte apoptotic process|
|regulation of interleukin-17 production|
|positive regulation of interleukin-2 production|
|regulation of platelet activation|
|regulation of T cell apoptotic process|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of insulin receptor signaling pathway|
|positive regulation of telomerase activity|
|immunological synapse|
|negative regulation of cellular response to insulin stimulus|
|membrane protein proteolysis|
|positive regulation of telomere maintenance via telomere lengthening|
|aggresome|
|negative regulation of leukocyte apoptotic process|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|regulation of lymphocyte apoptotic process|
|regulation of megakaryocyte differentiation|
|regulation of interleukin-2 production|
|regulation of telomere maintenance via telomerase|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of telomere maintenance via telomere lengthening|
|regulation of insulin receptor signaling pathway|
|positive regulation of DNA biosynthetic process|
|positive regulation of cytokine biosynthetic process|
|regulation of cellular response to insulin stimulus|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of telomere maintenance|
|regulation of coagulation|
|regulation of leukocyte apoptotic process|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cytokine biosynthetic process|
|positive regulation of adaptive immune response|
|regulation of DNA biosynthetic process|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of wound healing|
|platelet activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of T cell proliferation|
|microtubule organizing center|
|regulation of adaptive immune response|
|regulation of response to wounding|
|Fc-epsilon receptor signaling pathway|
|peptidyl-serine phosphorylation|
|positive regulation of chromosome organization|
|T cell receptor signaling pathway|
|positive regulation of DNA metabolic process|
|peptidyl-serine modification|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|protein kinase activity|
|Fc receptor signaling pathway|
|positive regulation of cell-cell adhesion|
|axon guidance|
|positive regulation of DNA-binding transcription factor activity|
|neuron projection guidance|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|regulation of T cell activation|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|protein serine/threonine kinase activity|
|axonogenesis|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|axon development|
|positive regulation of cell activation|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of body fluid levels|
|inflammatory response|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|response to wounding|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of cell activation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|regulation of cytokine production|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cell death|
|neuron differentiation|
|cell activation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.7|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.71|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.73|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.75|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.76|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKCQ Expression in NALM6 Cells: 2.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>