PRLR [The Human Chemical-Genetic Interaction Map Project]

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======= PRLR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRLR
  * **<color #00a2e8>Official Name</color>**: prolactin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5618|5618]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16471|P16471]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRLR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRLR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176761|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6Ra-bind|
|EpoR lig-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prolactin receptor activity|
|prolactin signaling pathway|
|ornithine decarboxylase activator activity|
|activation of Janus kinase activity|
|activation of transmembrane receptor protein tyrosine kinase activity|
|growth hormone receptor signaling pathway via JAK-STAT|
|endosome lumen|
|growth hormone receptor signaling pathway|
|cellular response to growth hormone stimulus|
|response to growth hormone|
|embryo implantation|
|peptide hormone binding|
|cytokine binding|
|lactation|
|cytokine receptor activity|
|body fluid secretion|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of cold-induced thermogenesis|
|steroid biosynthetic process|
|mammary gland development|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|regulation of cold-induced thermogenesis|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|hormone-mediated signaling pathway|
|female pregnancy|
|receptor complex|
|multi-multicellular organism process|
|T cell activation|
|steroid metabolic process|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|activation of protein kinase activity|
|lymphocyte activation|
|response to peptide hormone|
|external side of plasma membrane|
|gland development|
|response to peptide|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cell death|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|response to cytokine|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRLR Expression in NALM6 Cells: 0.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>