PRNP [The Human Chemical-Genetic Interaction Map Project]

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======= PRNP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRNP
  * **<color #00a2e8>Official Name</color>**: prion protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5621|5621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"F7VJQ1|P04156"|"F7VJQ1|P04156"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRNP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRNP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prion|
|Prion bPrPp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 8 metabotropic glutamate receptor binding|
|regulation of intracellular calcium activated chloride channel activity|
|negative regulation of dendritic spine maintenance|
|regulation of calcium ion import across plasma membrane|
|cupric ion binding|
|type 5 metabotropic glutamate receptor binding|
|cuprous ion binding|
|regulation of inorganic anion transmembrane transport|
|ATP-dependent protein binding|
|modulation of age-related behavioral decline|
|neuron projection maintenance|
|dendritic spine maintenance|
|regulation of chloride transport|
|regulation of anion channel activity|
|negative regulation of activated T cell proliferation|
|regulation of dendritic spine maintenance|
|negative regulation of long-term synaptic potentiation|
|negative regulation of amyloid-beta formation|
|negative regulation of interleukin-17 production|
|negative regulation of calcineurin-mediated signaling|
|negative regulation of calcineurin-NFAT signaling cascade|
|cellular copper ion homeostasis|
|negative regulation of amyloid precursor protein catabolic process|
|lamin binding|
|copper ion homeostasis|
|inclusion body|
|anchored component of external side of plasma membrane|
|negative regulation of T cell receptor signaling pathway|
|negative regulation of interleukin-2 production|
|calcium-mediated signaling using intracellular calcium source|
|negative regulation of synapse organization|
|glycosaminoglycan binding|
|regulation of amyloid-beta formation|
|negative regulation of antigen receptor-mediated signaling pathway|
|regulation of anion transmembrane transport|
|regulation of interleukin-17 production|
|negative regulation of calcium-mediated signaling|
|cellular response to copper ion|
|dendritic spine organization|
|positive regulation of protein targeting to membrane|
|long-term memory|
|negative regulation of interferon-gamma production|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|regulation of amyloid precursor protein catabolic process|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of calcineurin-mediated signaling|
|regulation of activated T cell proliferation|
|regulation of protein targeting to membrane|
|regulation of calcium ion import|
|cellular response to amyloid-beta|
|regulation of T cell receptor signaling pathway|
|neuron projection organization|
|regulation of long-term synaptic potentiation|
|response to copper ion|
|protein destabilization|
|cellular component maintenance|
|response to amyloid-beta|
|regulation of interleukin-2 production|
|tubulin binding|
|positive regulation of neuron apoptotic process|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of protein localization to plasma membrane|
|copper ion binding|
|negative regulation of T cell proliferation|
|positive regulation of protein localization to cell periphery|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of glutamate receptor signaling pathway|
|response to cadmium ion|
|extrinsic component of membrane|
|regulation of protein processing|
|regulation of protein maturation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|regulation of potassium ion transmembrane transport|
|amyloid-beta binding|
|regulation of protein targeting|
|postsynapse|
|postsynapse organization|
|regulation of protein tyrosine kinase activity|
|positive regulation of neuron death|
|regulation of protein localization to plasma membrane|
|regulation of anion transport|
|regulation of potassium ion transport|
|regulation of postsynapse organization|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|regulation of interferon-gamma production|
|protease binding|
|chaperone binding|
|cellular transition metal ion homeostasis|
|negative regulation of T cell activation|
|regulation of protein localization to cell periphery|
|memory|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of protein localization to membrane|
|ion channel binding|
|transition metal ion homeostasis|
|negative regulation of lymphocyte activation|
|cell cycle arrest|
|calcium-mediated signaling|
|negative regulation of cellular amide metabolic process|
|regulation of calcium ion transmembrane transport|
|positive regulation of intracellular protein transport|
|regulation of T cell proliferation|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of cell projection organization|
|regulation of synaptic plasticity|
|regulation of protein localization to membrane|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to metal ion|
|negative regulation of cell activation|
|signaling receptor activity|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of synapse organization|
|cellular response to inorganic substance|
|regulation of leukocyte proliferation|
|membrane raft|
|regulation of synapse structure or activity|
|regulation of intracellular protein transport|
|nuclear membrane|
|microtubule binding|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|synapse organization|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of transporter activity|
|aging|
|regulation of protein stability|
|regulation of leukocyte cell-cell adhesion|
|cognition|
|regulation of neuron death|
|regulation of T cell activation|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|protein homooligomerization|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|response to metal ion|
|response to oxidative stress|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|dendrite|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|positive regulation of establishment of protein localization|
|response to peptide|
|regulation of ion transmembrane transport|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|regulation of cellular protein localization|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|behavior|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.1|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.94|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.93|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6713
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRNP Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>