PROX1 [The Human Chemical-Genetic Interaction Map Project]

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======= PROX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PROX1
  * **<color #00a2e8>Official Name</color>**: prospero homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5629|5629]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92786|Q92786]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PROX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PROX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601546|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prox1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|branching involved in pancreas morphogenesis|
|acinar cell differentiation|
|positive regulation of forebrain neuron differentiation|
|otic placode formation|
|hepatocyte cell migration|
|optic placode formation|
|regulation of transcription involved in lymphatic endothelial cell fate commitment|
|optic placode formation involved in camera-type eye formation|
|olfactory placode formation|
|olfactory placode morphogenesis|
|lymphatic endothelial cell fate commitment|
|olfactory placode development|
|ventricular cardiac myofibril assembly|
|aorta smooth muscle tissue morphogenesis|
|DBD domain binding|
|negative regulation of bile acid metabolic process|
|positive regulation of sarcomere organization|
|negative regulation of bile acid biosynthetic process|
|epithelial cell proliferation involved in liver morphogenesis|
|hepatocyte proliferation|
|endocardium formation|
|pancreas morphogenesis|
|regulation of forebrain neuron differentiation|
|liver morphogenesis|
|lens fiber cell morphogenesis|
|atrial cardiac muscle tissue morphogenesis|
|endocardium morphogenesis|
|endothelial cell fate commitment|
|atrial cardiac muscle tissue development|
|cerebellar granule cell differentiation|
|LBD domain binding|
|regulation of sarcomere organization|
|cerebellar granular layer formation|
|embryonic retina morphogenesis in camera-type eye|
|lymphatic endothelial cell differentiation|
|otic vesicle formation|
|venous blood vessel morphogenesis|
|cerebellar granular layer morphogenesis|
|otic vesicle morphogenesis|
|positive regulation of cell cycle checkpoint|
|regulation of bile acid biosynthetic process|
|ventricular cardiac muscle cell development|
|ectodermal placode formation|
|ectodermal placode morphogenesis|
|regulation of bile acid metabolic process|
|ectodermal placode development|
|embryonic camera-type eye formation|
|lymphangiogenesis|
|endocardium development|
|cerebellar granular layer development|
|hepatocyte differentiation|
|lens fiber cell development|
|skeletal muscle thin filament assembly|
|epithelial cell fate commitment|
|otic vesicle development|
|venous blood vessel development|
|lymph vessel morphogenesis|
|nose development|
|ventricular cardiac muscle cell differentiation|
|skeletal myofibril assembly|
|dentate gyrus development|
|smooth muscle tissue development|
|regulation of transcription involved in cell fate commitment|
|cell differentiation in hindbrain|
|nuclear receptor binding|
|cerebellar cortex formation|
|dorsal spinal cord development|
|lens morphogenesis in camera-type eye|
|lymph vessel development|
|neuronal stem cell population maintenance|
|negative regulation of steroid biosynthetic process|
|cardiac myofibril assembly|
|negative regulation of steroid metabolic process|
|embryonic camera-type eye morphogenesis|
|lens fiber cell differentiation|
|aorta morphogenesis|
|cardiac atrium morphogenesis|
|cerebellar cortex morphogenesis|
|regulation of cell cycle checkpoint|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|embryonic eye morphogenesis|
|cardiac atrium development|
|positive regulation of cyclin-dependent protein kinase activity|
|cerebellum morphogenesis|
|embryonic camera-type eye development|
|positive regulation of heart growth|
|glandular epithelial cell differentiation|
|cell fate determination|
|ventricular septum morphogenesis|
|hindbrain morphogenesis|
|cerebellar cortex development|
|positive regulation of organ growth|
|ventricular cardiac muscle tissue morphogenesis|
|negative regulation of lipid biosynthetic process|
|retina morphogenesis in camera-type eye|
|aorta development|
|positive regulation of neural precursor cell proliferation|
|ventricular cardiac muscle tissue development|
|negative regulation of viral genome replication|
|positive regulation of striated muscle cell differentiation|
|cardiac muscle cell development|
|artery morphogenesis|
|regulation of heart growth|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle tissue morphogenesis|
|pancreas development|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|cardiac septum morphogenesis|
|positive regulation of organelle assembly|
|lens development in camera-type eye|
|muscle tissue morphogenesis|
|hippocampus development|
|negative regulation of viral life cycle|
|endothelial cell differentiation|
|negative regulation of lipid metabolic process|
|artery development|
|muscle organ morphogenesis|
|positive regulation of muscle cell differentiation|
|epithelial cell proliferation|
|regulation of steroid biosynthetic process|
|regulation of neural precursor cell proliferation|
|cardiac muscle cell differentiation|
|regulation of actomyosin structure organization|
|negative regulation of small molecule metabolic process|
|regulation of organ growth|
|regulation of viral genome replication|
|positive regulation of endothelial cell proliferation|
|endothelium development|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|negative regulation of viral process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of endothelial cell migration|
|gland morphogenesis|
|regulation of striated muscle cell differentiation|
|regulation of cyclin-dependent protein kinase activity|
|cerebellum development|
|cellular component assembly involved in morphogenesis|
|spinal cord development|
|cardiac septum development|
|limbic system development|
|metencephalon development|
|camera-type eye morphogenesis|
|regulation of circadian rhythm|
|actomyosin structure organization|
|regulation of steroid metabolic process|
|cardiocyte differentiation|
|ear morphogenesis|
|liver development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of endothelial cell proliferation|
|hepaticobiliary system development|
|epithelial tube formation|
|striated muscle cell development|
|stem cell population maintenance|
|maintenance of cell number|
|retina development in camera-type eye|
|positive regulation of epithelial cell migration|
|circadian rhythm|
|regulation of viral life cycle|
|eye morphogenesis|
|tube formation|
|muscle cell development|
|hindbrain development|
|regulation of muscle cell differentiation|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|neural tube development|
|negative regulation of DNA-binding transcription factor activity|
|cardiac muscle tissue development|
|morphogenesis of a branching structure|
|lung development|
|cardiac chamber development|
|positive regulation of developmental growth|
|regulation of cellular ketone metabolic process|
|respiratory tube development|
|pallium development|
|central nervous system neuron differentiation|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|epithelial cell development|
|inner ear development|
|respiratory system development|
|positive regulation of supramolecular fiber organization|
|striated muscle cell differentiation|
|regulation of viral process|
|negative regulation of multi-organism process|
|transcription regulatory region DNA binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|regulation of organelle assembly|
|ear development|
|actin filament organization|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|sensory organ morphogenesis|
|telencephalon development|
|positive regulation of growth|
|kidney development|
|rhythmic process|
|renal system development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|camera-type eye development|
|urogenital system development|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|positive regulation of cell cycle|
|forebrain development|
|regulation of actin filament-based process|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|gland development|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|morphogenesis of an epithelium|
|embryonic organ development|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|muscle structure development|
|blood vessel development|
|actin cytoskeleton organization|
|response to nutrient levels|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|heart development|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|sensory organ development|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|cell morphogenesis|
|brain development|
|organelle assembly|
|regulation of multi-organism process|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.81|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5836
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PROX1 Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>