PSTK [The Human Chemical-Genetic Interaction Map Project]

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======= PSTK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSTK
  * **<color #00a2e8>Official Name</color>**: phosphoseryl-tRNA kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=118672|118672]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IV42|Q8IV42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSTK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSTK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KTI12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|selenocysteinyl-tRNA(Sec) biosynthetic process|
|tRNA binding|
|kinase activity|
|tRNA metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|RNA biosynthetic process|
|cellular amide metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-3.01|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.92|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.36|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.34|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.22|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.19|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.11|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.02|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.99|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.97|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.97|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.94|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.91|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.87|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.86|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.83|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.81|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.81|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.78|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.78|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.77|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.76|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.76|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.75|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.73|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.72|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.71|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eefsec|EEFSEC]]|0.627|
|[[:human genes:s:sephs2|SEPHS2]]|0.576|
|[[:human genes:g:gpx4|GPX4]]|0.491|
|[[:human genes:s:sepsecs|SEPSECS]]|0.444|
|[[:human genes:s:secisbp2|SECISBP2]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 156/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|8/28|
|bone|9/26|
|breast|7/33|
|central nervous system|20/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|5/21|
|liver|7/20|
|lung|15/75|
|lymphocyte|7/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|6/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1280
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSTK Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>