PTAFR [The Human Chemical-Genetic Interaction Map Project]

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======= PTAFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTAFR
  * **<color #00a2e8>Official Name</color>**: platelet activating factor receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5724|5724]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25105|P25105]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTAFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTAFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1374385, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcytosis|
|cellular response to gravity|
|positive regulation of transcytosis|
|regulation of maternal process involved in parturition|
|positive regulation of maternal process involved in parturition|
|response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine|
|cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine|
|regulation of voltage-gated chloride channel activity|
|positive regulation of voltage-gated chloride channel activity|
|platelet activating factor receptor activity|
|positive regulation of inorganic anion transmembrane transport|
|response to symbiotic bacterium|
|positive regulation of leukocyte tethering or rolling|
|positive regulation of neutrophil activation|
|positive regulation of neutrophil degranulation|
|response to symbiont|
|positive regulation of anion channel activity|
|lipopolysaccharide receptor activity|
|positive regulation of gastro-intestinal system smooth muscle contraction|
|regulation of gastro-intestinal system smooth muscle contraction|
|regulation of inorganic anion transmembrane transport|
|positive regulation of sensory perception of pain|
|positive regulation of anion transmembrane transport|
|regulation of neutrophil degranulation|
|regulation of leukocyte tethering or rolling|
|regulation of chloride transport|
|regulation of anion channel activity|
|response to gravity|
|regulation of neutrophil activation|
|G protein-coupled purinergic nucleotide receptor activity|
|G protein-coupled purinergic nucleotide receptor signaling pathway|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of inositol phosphate biosynthetic process|
|positive regulation of interleukin-6 biosynthetic process|
|inositol trisphosphate biosynthetic process|
|regulation of inositol phosphate biosynthetic process|
|parturition|
|positive regulation of cellular extravasation|
|transcytosis|
|inositol trisphosphate metabolic process|
|regulation of leukocyte adhesion to vascular endothelial cell|
|G protein-coupled purinergic receptor signaling pathway|
|purinergic nucleotide receptor signaling pathway|
|mitogen-activated protein kinase binding|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of leukocyte degranulation|
|positive regulation of alcohol biosynthetic process|
|regulation of anion transmembrane transport|
|inositol phosphate biosynthetic process|
|purinergic receptor signaling pathway|
|regulation of cellular extravasation|
|positive regulation of vasoconstriction|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of smooth muscle contraction|
|lipopolysaccharide-mediated signaling pathway|
|lipopolysaccharide binding|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|response to dexamethasone|
|positive regulation of phospholipase C activity|
|negative regulation of blood pressure|
|positive regulation of muscle contraction|
|regulation of phospholipase C activity|
|regulation of leukocyte degranulation|
|positive regulation of anion transport|
|positive regulation of regulated secretory pathway|
|cellular response to cAMP|
|cellular response to fatty acid|
|positive regulation of blood vessel diameter|
|inositol phosphate metabolic process|
|regulation of vasoconstriction|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of myeloid leukocyte mediated immunity|
|polyol biosynthetic process|
|positive regulation of phospholipase activity|
|regulation of smooth muscle contraction|
|positive regulation of nervous system process|
|positive regulation of cytokine biosynthetic process|
|positive regulation of blood circulation|
|phosphatidylinositol-mediated signaling|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|interferon-gamma-mediated signaling pathway|
|tertiary granule membrane|
|inositol lipid-mediated signaling|
|regulation of alcohol biosynthetic process|
|positive regulation of reproductive process|
|positive regulation of carbohydrate metabolic process|
|response to fatty acid|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of exocytosis|
|regulation of carbohydrate biosynthetic process|
|positive regulation of interleukin-6 production|
|response to antineoplastic agent|
|regulation of anion transport|
|regulation of lipase activity|
|secretory granule membrane|
|response to cAMP|
|positive regulation of ion transmembrane transporter activity|
|phospholipid binding|
|regulation of cytokine biosynthetic process|
|polyol metabolic process|
|positive regulation of transporter activity|
|alcohol biosynthetic process|
|positive regulation of translation|
|positive regulation of leukocyte migration|
|cellular response to ammonium ion|
|regulation of smooth muscle cell proliferation|
|positive regulation of leukocyte mediated immunity|
|response to organophosphorus|
|regulation of nervous system process|
|positive regulation of small molecule metabolic process|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of cellular carbohydrate metabolic process|
|regulation of interleukin-6 production|
|regulation of tube size|
|response to glucocorticoid|
|regulation of tumor necrosis factor production|
|cytokine production|
|positive regulation of cellular amide metabolic process|
|response to purine-containing compound|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of ion transmembrane transport|
|regulation of reproductive process|
|regulation of muscle contraction|
|response to corticosteroid|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|regulation of blood pressure|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|response to ammonium ion|
|organic hydroxy compound biosynthetic process|
|cellular response to molecule of bacterial origin|
|response to ketone|
|regulation of leukocyte migration|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|regulation of leukocyte mediated immunity|
|cellular response to acid chemical|
|multi-multicellular organism process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of exocytosis|
|regulation of muscle system process|
|positive regulation of cell-cell adhesion|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|response to lipopolysaccharide|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|alcohol metabolic process|
|response to molecule of bacterial origin|
|response to steroid hormone|
|response to acid chemical|
|regulation of translation|
|blood circulation|
|circulatory system process|
|regulation of cell-cell adhesion|
|cellular response to drug|
|positive regulation of leukocyte activation|
|regulation of cellular amide metabolic process|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|positive regulation of cytokine production|
|organic hydroxy compound metabolic process|
|regulation of immune effector process|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|regulation of system process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|G protein-coupled receptor activity|
|regulation of secretion by cell|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|organophosphate metabolic process|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|multi-organism reproductive process|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTAFR Expression in NALM6 Cells: 2.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>