PTBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PTBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTBP1
  * **<color #00a2e8>Official Name</color>**: polypyrimidine tract binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5725|5725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26599|P26599]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly-pyrimidine tract binding|
|IRES-dependent viral translational initiation|
|viral translation|
|pre-mRNA binding|
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|negative regulation of mRNA splicing, via spliceosome|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|positive regulation of calcium-mediated signaling|
|positive regulation of protein dephosphorylation|
|negative regulation of muscle cell differentiation|
|positive regulation of dephosphorylation|
|regulation of alternative mRNA splicing, via spliceosome|
|negative regulation of mRNA metabolic process|
|fibroblast growth factor receptor signaling pathway|
|regulation of calcium-mediated signaling|
|regulation of mRNA splicing, via spliceosome|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|viral gene expression|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of protein dephosphorylation|
|regulation of muscle cell differentiation|
|regulation of dephosphorylation|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|mRNA processing|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|mRNA metabolic process|
|viral process|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|RNA processing|
|negative regulation of developmental process|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.03|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.79|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.78|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.71|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.76|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.77|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.8|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.85|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.92|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.94|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.96|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.22|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.52|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cd2bp2|CD2BP2]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 89/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|2/26|
|breast|6/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|9/21|
|liver|3/20|
|lung|8/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|6/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1368
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTBP1 Expression in NALM6 Cells: 8.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>