PTGES3 [The Human Chemical-Genetic Interaction Map Project]

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======= PTGES3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGES3
  * **<color #00a2e8>Official Name</color>**: prostaglandin E synthase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10728|10728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15185|Q15185]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGES3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGES3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prostaglandin-E synthase activity|
|telomerase holoenzyme complex assembly|
|telomerase activity|
|chaperone complex|
|cyclooxygenase pathway|
|chaperone-mediated protein complex assembly|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|DNA polymerase binding|
|telomerase holoenzyme complex|
|telomere maintenance via telomerase|
|telomere maintenance via telomere lengthening|
|chaperone cofactor-dependent protein refolding|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|RNA-dependent DNA biosynthetic process|
|positive regulation of telomerase activity|
|de novo posttranslational protein folding|
|de novo protein folding|
|Hsp90 protein binding|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|chromosome, telomeric region|
|regulation of telomerase activity|
|arachidonic acid metabolic process|
|chaperone-mediated protein folding|
|positive regulation of DNA biosynthetic process|
|regulation of cellular response to heat|
|fatty acid derivative biosynthetic process|
|telomere maintenance|
|telomere organization|
|chaperone binding|
|unsaturated fatty acid metabolic process|
|DNA biosynthetic process|
|icosanoid metabolic process|
|regulation of DNA biosynthetic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|xenobiotic metabolic process|
|unfolded protein binding|
|fatty acid derivative metabolic process|
|protein stabilization|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|positive regulation of DNA metabolic process|
|protein folding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of protein stability|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|anatomical structure homeostasis|
|regulation of DNA metabolic process|
|ribonucleoprotein complex biogenesis|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|protein-containing complex|
|positive regulation of transferase activity|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular protein-containing complex assembly|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|regulation of transferase activity|
|oxoacid metabolic process|
|organic acid metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.17|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.88|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.75|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.83|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.88|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.13|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.84|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|4.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3756
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGES3 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>