PTPN23 [The Human Chemical-Genetic Interaction Map Project]

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======= PTPN23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN23
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25930|25930]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3S7|Q9H3S7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606584|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRO1|
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of homophilic cell adhesion|
|positive regulation of Wnt protein secretion|
|regulation of Wnt protein secretion|
|regulation of homophilic cell adhesion|
|positive regulation of early endosome to late endosome transport|
|positive regulation of cytoplasmic transport|
|regulation of early endosome to late endosome transport|
|early endosome to late endosome transport|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|vesicle-mediated transport between endosomal compartments|
|regulation of cytoplasmic transport|
|positive regulation of adherens junction organization|
|endocytic recycling|
|negative regulation of epithelial cell migration|
|regulation of adherens junction organization|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|ciliary basal body|
|cytosolic transport|
|positive regulation of intracellular transport|
|protein dephosphorylation|
|regulation of epithelial cell migration|
|endosomal transport|
|positive regulation of cell-cell adhesion|
|early endosome|
|negative regulation of cell migration|
|endosome|
|positive regulation of protein secretion|
|negative regulation of cell motility|
|nuclear body|
|positive regulation of peptide secretion|
|dephosphorylation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|cilium assembly|
|regulation of intracellular transport|
|cilium organization|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|regulation of peptide secretion|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of cell adhesion|
|protein catabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|regulation of secretion|
|regulation of cell migration|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.49|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.16|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.14|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.07|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.06|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.06|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.86|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.77|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.77|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.71|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.75|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.608|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 564/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|27/28|
|bone|20/26|
|breast|28/33|
|central nervous system|33/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|16/16|
|kidney|19/21|
|liver|16/20|
|lung|50/75|
|lymphocyte|15/16|
|ovary|20/26|
|pancreas|15/24|
|peripheral nervous system|8/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN23 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>