PVR [The Human Chemical-Genetic Interaction Map Project]

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======= PVR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PVR
  * **<color #00a2e8>Official Name</color>**: PVR cell adhesion molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5817|5817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15151|P15151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PVR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PVR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. {ECO:0000269|PubMed:15471548, ECO:0000269|PubMed:15607800}. (Microbial infection) Acts as a receptor for Pseudorabies virus. {ECO:0000269|PubMed:9616127}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|V-set|
|C2-set 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|susceptibility to T cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of response to tumor cell|
|susceptibility to natural killer cell mediated cytotoxicity|
|positive regulation of immune response to tumor cell|
|regulation of immune response to tumor cell|
|regulation of response to tumor cell|
|positive regulation of T cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated immunity|
|regulation of T cell mediated cytotoxicity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|positive regulation of T cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|cell adhesion molecule binding|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|virus receptor activity|
|regulation of leukocyte mediated cytotoxicity|
|adherens junction organization|
|viral entry into host cell|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|entry into host cell|
|entry into host|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|cell-cell adherens junction|
|positive regulation of leukocyte mediated immunity|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|interaction with host|
|regulation of adaptive immune response|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|viral life cycle|
|signaling receptor activity|
|regulation of leukocyte mediated immunity|
|cell junction organization|
|positive regulation of immune effector process|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|focal adhesion|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|cell surface|
|viral process|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of response to stress|
|extracellular space|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10661
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PVR Expression in NALM6 Cells: 2.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>