PVRL1 [The Human Chemical-Genetic Interaction Map Project]

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======= PVRL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NECTIN1
  * **<color #00a2e8>Official Name</color>**: nectin cell adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5818|5818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15223|Q15223]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PVRL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PVRL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600644|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity. {ECO:0000269|PubMed:21980294}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|ig|
|C2-set 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth cone membrane|
|desmosome organization|
|virion attachment to host cell|
|virion binding|
|adhesion of symbiont to host cell|
|protein localization to cell junction|
|enamel mineralization|
|adhesion of symbiont to host|
|tooth mineralization|
|integral component of presynaptic active zone membrane|
|apical junction complex|
|cell-cell contact zone|
|amelogenesis|
|lens morphogenesis in camera-type eye|
|hippocampal mossy fiber to CA3 synapse|
|coreceptor activity|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|cell adhesion molecule binding|
|adherens junction|
|iron ion transport|
|virus receptor activity|
|lens development in camera-type eye|
|odontogenesis of dentin-containing tooth|
|adherens junction organization|
|biomineralization|
|biomineral tissue development|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|cell-cell adherens junction|
|regulation of synapse assembly|
|camera-type eye morphogenesis|
|transition metal ion transport|
|odontogenesis|
|cell-cell junction organization|
|retina development in camera-type eye|
|eye morphogenesis|
|interaction with host|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|carbohydrate binding|
|viral life cycle|
|signaling receptor activity|
|cell junction organization|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|sensory organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|cell-cell adhesion|
|cell part morphogenesis|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|metal ion transport|
|neuron projection development|
|intracellular membrane-bounded organelle|
|viral process|
|cell morphogenesis|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|cation transport|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|neuron differentiation|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|ion transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|tissue development|
|immune response|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.85|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.71|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PVRL1 Expression in NALM6 Cells: -1.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>