PVRL3 [The Human Chemical-Genetic Interaction Map Project]

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======= PVRL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NECTIN3
  * **<color #00a2e8>Official Name</color>**: nectin cell adhesion molecule 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25945|25945]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQS3|Q9NQS3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PVRL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PVRL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607147|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis- mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|I-set|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to cell junction|
|apical junction complex|
|cell-cell contact zone|
|lens morphogenesis in camera-type eye|
|hippocampal mossy fiber to CA3 synapse|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|retina morphogenesis in camera-type eye|
|integral component of postsynaptic density membrane|
|establishment of protein localization to plasma membrane|
|cell adhesion molecule binding|
|lens development in camera-type eye|
|adherens junction organization|
|cell-cell adherens junction|
|camera-type eye morphogenesis|
|retina development in camera-type eye|
|eye morphogenesis|
|spermatid development|
|spermatid differentiation|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|fertilization|
|cell-cell junction|
|protein localization to plasma membrane|
|signaling receptor activity|
|cell junction organization|
|protein localization to cell periphery|
|germ cell development|
|sensory organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|establishment of protein localization to membrane|
|axon|
|camera-type eye development|
|cellular process involved in reproduction in multicellular organism|
|eye development|
|visual system development|
|sensory system development|
|dendrite|
|protein localization to membrane|
|cell-cell adhesion|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18713
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PVRL3 Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>