RAB11A [The Human Chemical-Genetic Interaction Map Project]

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======= RAB11A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB11A
  * **<color #00a2e8>Official Name</color>**: RAB11A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8766|8766]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62491|P62491]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB11A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB11A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. {ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of multivesicular body size|
|postsynaptic recycling endosome|
|exosomal secretion|
|regulation of endosome size|
|extracellular exosome biogenesis|
|astral microtubule organization|
|amyloid-beta clearance by transcytosis|
|kinetochore microtubule|
|plasma membrane to endosome transport|
|extracellular vesicle biogenesis|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|neurotransmitter receptor transport, endosome to plasma membrane|
|endosome to plasma membrane protein transport|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|myosin V binding|
|transcytosis|
|establishment of protein localization to postsynaptic membrane|
|melanosome transport|
|amyloid-beta clearance|
|pigment granule transport|
|establishment of melanosome localization|
|establishment of pigment granule localization|
|melanosome localization|
|pigment granule localization|
|positive regulation of G2/M transition of mitotic cell cycle|
|regulation of long-term neuronal synaptic plasticity|
|retrograde transport, endosome to plasma membrane|
|multivesicular body assembly|
|positive regulation of cell cycle G2/M phase transition|
|multivesicular body organization|
|multivesicular body|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|renal water homeostasis|
|mitotic spindle assembly|
|receptor localization to synapse|
|positive regulation of axon extension|
|mitotic metaphase plate congression|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|cellular pigmentation|
|establishment of protein localization to plasma membrane|
|cytoplasmic microtubule organization|
|regulation of neuronal synaptic plasticity|
|syntaxin binding|
|cleavage furrow|
|metaphase plate congression|
|positive regulation of protein localization to plasma membrane|
|phagocytic vesicle|
|positive regulation of protein localization to cell periphery|
|protein localization to synapse|
|multicellular organismal water homeostasis|
|Rab protein signal transduction|
|water homeostasis|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle organization|
|endosome organization|
|positive regulation of mitotic cell cycle phase transition|
|Schaffer collateral - CA1 synapse|
|recycling endosome membrane|
|positive regulation of axonogenesis|
|regulation of cytokinesis|
|pigmentation|
|transport vesicle|
|vesicle-mediated transport to the plasma membrane|
|positive regulation of cell cycle phase transition|
|regulation of protein localization to plasma membrane|
|ciliary basal body-plasma membrane docking|
|regulation of axon extension|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|regulation of extent of cell growth|
|renal system process|
|regulation of protein localization to cell periphery|
|recycling endosome|
|spindle pole|
|positive regulation of protein localization to membrane|
|vesicle-mediated transport in synapse|
|positive regulation of epithelial cell migration|
|vesicle|
|sister chromatid segregation|
|cytoplasmic vesicle membrane|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|spindle organization|
|positive regulation of cell morphogenesis involved in differentiation|
|microtubule organizing center|
|positive regulation of cell growth|
|regulation of cell division|
|trans-Golgi network|
|organelle localization by membrane tethering|
|positive regulation of developmental growth|
|establishment of vesicle localization|
|membrane docking|
|regulation of cell size|
|protein localization to plasma membrane|
|regulation of axonogenesis|
|vesicle localization|
|regulation of protein localization to membrane|
|regulation of synaptic plasticity|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|nuclear chromosome segregation|
|regulation of epithelial cell migration|
|endosomal transport|
|protein localization to cell periphery|
|microtubule binding|
|Ras protein signal transduction|
|cytoplasmic vesicle|
|protein-containing complex localization|
|positive regulation of growth|
|establishment of protein localization to membrane|
|endosome|
|chromosome segregation|
|positive regulation of neuron projection development|
|nuclear division|
|positive regulation of cell cycle process|
|axon|
|vesicle organization|
|regulation of cell morphogenesis involved in differentiation|
|organelle fission|
|small GTPase mediated signal transduction|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|GTPase activity|
|cilium assembly|
|glutamatergic synapse|
|post-translational protein modification|
|establishment of organelle localization|
|cilium organization|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|GTP binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|endomembrane system organization|
|establishment of protein localization to organelle|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|regulation of cell morphogenesis|
|centrosome|
|regulation of body fluid levels|
|regulation of neuron projection development|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of growth|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|organelle assembly|
|exocytosis|
|neuron development|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|intracellular protein transport|
|cell cycle process|
|secretion by cell|
|neuron differentiation|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cytoskeleton organization|
|chemical homeostasis|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cell cycle|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.38|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.01|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.77|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.71|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.97|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.06|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.07|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.32|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|4.8|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|5.27|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|6.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trappc9|TRAPPC9]]|0.582|
|[[:human genes:t:trappc10|TRAPPC10]]|0.538|
|[[:human genes:p:pitpnb|PITPNB]]|0.48|
|[[:human genes:a:ap1b1|AP1B1]]|0.416|
|[[:human genes:a:ap1g1|AP1G1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9044
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB11A Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>