RAB11B [The Human Chemical-Genetic Interaction Map Project]

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======= RAB11B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB11B
  * **<color #00a2e8>Official Name</color>**: RAB11B, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9230|9230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15907|Q15907]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB11B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB11B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604198|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|constitutive secretory pathway|
|amyloid-beta clearance by transcytosis|
|insulin secretion involved in cellular response to glucose stimulus|
|regulation of endocytic recycling|
|cellular response to acidic pH|
|receptor recycling|
|anchored component of synaptic vesicle membrane|
|myosin V binding|
|transcytosis|
|melanosome transport|
|amyloid-beta clearance|
|pigment granule transport|
|establishment of melanosome localization|
|establishment of pigment granule localization|
|response to acidic pH|
|cellular response to pH|
|melanosome localization|
|pigment granule localization|
|retrograde transport, endosome to plasma membrane|
|transferrin transport|
|regulation of protein localization to cell surface|
|insulin secretion|
|response to pH|
|cellular pigmentation|
|peptide hormone secretion|
|phagocytic vesicle|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|iron ion transport|
|hormone secretion|
|Rab protein signal transduction|
|cellular response to monosaccharide stimulus|
|phagocytic vesicle membrane|
|GDP binding|
|cellular response to carbohydrate stimulus|
|hormone transport|
|recycling endosome membrane|
|cellular glucose homeostasis|
|pigmentation|
|vesicle-mediated transport to the plasma membrane|
|regulation of anion transport|
|receptor metabolic process|
|recycling endosome|
|synaptic vesicle|
|transition metal ion transport|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|establishment of vesicle localization|
|glucose homeostasis|
|vesicle localization|
|carbohydrate homeostasis|
|endosomal transport|
|Ras protein signal transduction|
|establishment of protein localization to membrane|
|endosome|
|cadherin binding|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of intracellular transport|
|post-translational protein modification|
|establishment of organelle localization|
|GTP binding|
|protein localization to membrane|
|regulation of hormone levels|
|regulation of cellular protein localization|
|cell junction|
|regulation of vesicle-mediated transport|
|organelle localization|
|metal ion transport|
|regulation of ion transport|
|regulated exocytosis|
|cellular chemical homeostasis|
|exocytosis|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|intracellular protein transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12173
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB11B Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>