RAB13 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB13
  * **<color #00a2e8>Official Name</color>**: RAB13, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5872|5872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51153|P51153]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602672|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gtr1 RagA|
|Ras|
|SRPRB|
|GTP EFTU|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-Golgi network to recycling endosome transport|
|establishment of Sertoli cell barrier|
|insulin-responsive compartment|
|endothelial cell chemotaxis|
|protein kinase A signaling|
|Sertoli cell development|
|Sertoli cell differentiation|
|bicellular tight junction assembly|
|tight junction assembly|
|endocytic recycling|
|tight junction organization|
|cortical actin cytoskeleton organization|
|apical junction assembly|
|cortical cytoskeleton organization|
|lateral plasma membrane|
|endocytic vesicle|
|endothelial cell migration|
|Rab protein signal transduction|
|recycling endosome membrane|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|cell-cell junction assembly|
|recycling endosome|
|bicellular tight junction|
|male gonad development|
|development of primary male sexual characteristics|
|cell-cell junction organization|
|cytoplasmic vesicle membrane|
|male sex differentiation|
|cellular response to insulin stimulus|
|cell junction assembly|
|trans-Golgi network|
|ameboidal-type cell migration|
|lamellipodium|
|protein localization to plasma membrane|
|epithelial cell development|
|cell chemotaxis|
|gonad development|
|cell junction organization|
|development of primary sexual characteristics|
|response to insulin|
|endosomal transport|
|protein localization to cell periphery|
|Ras protein signal transduction|
|cytoplasmic vesicle|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|small GTPase mediated signal transduction|
|neuron projection|
|cellular response to peptide|
|GTPase activity|
|post-translational protein modification|
|GTP binding|
|response to peptide hormone|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|protein localization to membrane|
|actin cytoskeleton organization|
|cell junction|
|chemotaxis|
|taxis|
|actin filament-based process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|neuron development|
|response to hormone|
|cell migration|
|Golgi apparatus|
|intracellular protein transport|
|response to organonitrogen compound|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|locomotion|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.25|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.09|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB13 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>