RAB14 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB14
  * **<color #00a2e8>Official Name</color>**: RAB14, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51552|51552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61106|P61106]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612673|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion. {ECO:0000250, ECO:0000269|PubMed:22595670}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagolysosome assembly involved in apoptotic cell clearance|
|nuclear outer membrane-endoplasmic reticulum membrane network|
|phagosome maturation involved in apoptotic cell clearance|
|phagolysosome assembly|
|trans-Golgi network transport vesicle|
|myosin V binding|
|Golgi to endosome transport|
|Golgi stack|
|endocytic recycling|
|apoptotic cell clearance|
|phagosome maturation|
|lysosome organization|
|lytic vacuole organization|
|rough endoplasmic reticulum|
|phagocytic vesicle|
|Rab protein signal transduction|
|tertiary granule membrane|
|GDP binding|
|fibroblast growth factor receptor signaling pathway|
|recycling endosome membrane|
|intracellular|
|post-Golgi vesicle-mediated transport|
|phosphatidylinositol biosynthetic process|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|recycling endosome|
|late endosome|
|regulation of embryonic development|
|vacuole organization|
|cytosolic transport|
|early endosome membrane|
|phosphatidylinositol metabolic process|
|trans-Golgi network|
|cilium|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|endosomal transport|
|phospholipid biosynthetic process|
|Ras protein signal transduction|
|lysosome|
|early endosome|
|vesicle organization|
|lysosomal membrane|
|glycerophospholipid metabolic process|
|small GTPase mediated signal transduction|
|phagocytosis|
|GTPase activity|
|defense response to bacterium|
|Golgi vesicle transport|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|GTP binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to growth factor|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|response to bacterium|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|leukocyte activation|
|defense response to other organism|
|cellular lipid metabolic process|
|intracellular protein transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.41|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.08|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.04|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.78|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.75|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.72|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15818
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB14 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>