RAB23 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB23
  * **<color #00a2e8>Official Name</color>**: RAB23, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51715|51715]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULC3|Q9ULC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:22452336}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein import into nucleus|
|negative regulation of protein import|
|craniofacial suture morphogenesis|
|negative regulation of nucleocytoplasmic transport|
|GTP metabolic process|
|negative regulation of protein localization to nucleus|
|guanosine-containing compound metabolic process|
|negative regulation of intracellular protein transport|
|cellular defense response|
|regulation of protein import into nucleus|
|regulation of protein import|
|negative regulation of intracellular transport|
|purine ribonucleoside triphosphate metabolic process|
|phagocytic vesicle|
|purine ribonucleoside metabolic process|
|autophagosome assembly|
|purine nucleoside metabolic process|
|autophagosome organization|
|cranial skeletal system development|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|autophagosome|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|ribonucleoside metabolic process|
|nucleoside triphosphate metabolic process|
|regulation of nucleocytoplasmic transport|
|nucleoside metabolic process|
|negative regulation of cellular protein localization|
|bone morphogenesis|
|regulation of protein localization to nucleus|
|vacuole organization|
|glycosyl compound metabolic process|
|macroautophagy|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|bone development|
|endosome membrane|
|regulation of intracellular protein transport|
|skeletal system morphogenesis|
|Ras protein signal transduction|
|autophagy|
|process utilizing autophagic mechanism|
|purine ribonucleotide metabolic process|
|small GTPase mediated signal transduction|
|ribonucleotide metabolic process|
|GTPase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|cilium assembly|
|regulation of intracellular transport|
|cilium organization|
|purine-containing compound metabolic process|
|GTP binding|
|nucleotide metabolic process|
|plasma membrane bounded cell projection assembly|
|nucleoside phosphate metabolic process|
|cell projection assembly|
|negative regulation of transport|
|centrosome|
|skeletal system development|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|cell junction|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|organelle assembly|
|organophosphate metabolic process|
|regulation of cellular localization|
|animal organ morphogenesis|
|intracellular protein transport|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|defense response|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|small molecule metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17711
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB23 Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>