RAB25 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB25
  * **<color #00a2e8>Official Name</color>**: RAB25, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57111|57111]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57735|P57735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612942|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pseudopodium membrane|
|pseudopodium organization|
|myosin V binding|
|pseudopodium|
|epithelial cell morphogenesis|
|Rab protein signal transduction|
|recycling endosome|
|positive regulation of epithelial cell migration|
|epithelial cell development|
|regulation of epithelial cell migration|
|Ras protein signal transduction|
|cytoplasmic vesicle|
|endosome|
|small GTPase mediated signal transduction|
|GTPase activity|
|GTP binding|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|epithelial cell differentiation|
|cell morphogenesis|
|exocytosis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|intracellular protein transport|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|cell development|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12788
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB25 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>