RAB34 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB34 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB34
  * **<color #00a2e8>Official Name</color>**: RAB34, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83871|83871]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"P0DI83|Q9BZG1"|"P0DI83|Q9BZG1"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB34&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB34|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610917|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagosome-lysosome fusion|
|macropinocytosis|
|Golgi cisterna|
|pinocytosis|
|Ral GTPase binding|
|phagolysosome assembly|
|GTP-dependent protein binding|
|positive regulation of smoothened signaling pathway|
|Golgi to plasma membrane protein transport|
|Golgi stack|
|phagosome maturation|
|lysosome localization|
|establishment of protein localization to plasma membrane|
|lytic vacuole organization|
|lysosome organization|
|Golgi to plasma membrane transport|
|phagocytic vesicle|
|vesicle fusion|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|organelle membrane fusion|
|regulation of smoothened signaling pathway|
|vesicle-mediated transport to the plasma membrane|
|ruffle membrane|
|organelle fusion|
|post-Golgi vesicle-mediated transport|
|vacuole organization|
|membrane fusion|
|vesicle|
|protein localization to plasma membrane|
|cilium|
|antigen processing and presentation|
|protein localization to cell periphery|
|Ras protein signal transduction|
|establishment of protein localization to membrane|
|vesicle organization|
|small GTPase mediated signal transduction|
|phagocytosis|
|GTPase activity|
|Golgi vesicle transport|
|GTP binding|
|protein localization to membrane|
|endocytosis|
|organelle localization|
|import into cell|
|perinuclear region of cytoplasm|
|organelle assembly|
|membrane organization|
|Golgi apparatus|
|intracellular protein transport|
|cell projection organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.79|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gpihbp1|GPIHBP1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3413
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB34 Expression in NALM6 Cells: 3.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>