RAB38 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB38
  * **<color #00a2e8>Official Name</color>**: RAB38, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23682|23682]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57729|P57729]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606281|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q8QZZ8, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Gtr1 RagA|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BLOC-2 complex binding|
|AP-3 adaptor complex binding|
|positive regulation of phosphatidylcholine biosynthetic process|
|regulation of phosphatidylcholine biosynthetic process|
|early endosome lumen|
|AP-1 adaptor complex binding|
|melanosome assembly|
|platelet dense granule organization|
|AP-2 adaptor complex binding|
|endosome to pigment granule transport|
|endosome to melanosome transport|
|pigment granule maturation|
|cellular pigment accumulation|
|pigment accumulation|
|positive regulation of phospholipid biosynthetic process|
|mitochondria-associated endoplasmic reticulum membrane|
|melanosome membrane|
|regulation of phospholipid biosynthetic process|
|GTP-dependent protein binding|
|melanosome organization|
|pigment granule organization|
|phagosome acidification|
|pigment cell differentiation|
|secretory granule organization|
|developmental pigmentation|
|phagosome maturation|
|intracellular pH reduction|
|cellular pigmentation|
|positive regulation of phospholipid metabolic process|
|pH reduction|
|phagocytic vesicle|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|positive regulation of lipid biosynthetic process|
|regulation of phospholipid metabolic process|
|regulation of intracellular pH|
|regulation of cellular pH|
|pigmentation|
|regulation of pH|
|melanosome|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|positive regulation of lipid metabolic process|
|trans-Golgi network|
|regulation of lipid biosynthetic process|
|developmental maturation|
|Ras protein signal transduction|
|lysosome|
|early endosome|
|vesicle organization|
|small GTPase mediated signal transduction|
|GTPase activity|
|post-translational protein modification|
|GTP binding|
|regulation of lipid metabolic process|
|endomembrane system organization|
|mitochondrion organization|
|protein localization to membrane|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|organelle assembly|
|ion homeostasis|
|cellular homeostasis|
|intracellular protein transport|
|endoplasmic reticulum|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|mitochondrion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14932
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB38 Expression in NALM6 Cells: -1.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>