RAB3GAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB3GAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB3GAP2
  * **<color #00a2e8>Official Name</color>**: RAB3 GTPase activating non-catalytic protein subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25782|25782]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2M9|Q9H2M9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB3GAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB3GAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. {ECO:0000269|PubMed:9733780}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of protein localization to endoplasmic reticulum membrane|
|positive regulation of endoplasmic reticulum tubular network organization|
|positive regulation of protein lipidation|
|regulation of endoplasmic reticulum tubular network organization|
|positive regulation of lipoprotein metabolic process|
|regulation of protein lipidation|
|positive regulation of autophagosome assembly|
|regulation of lipoprotein metabolic process|
|positive regulation of vacuole organization|
|enzyme regulator activity|
|regulation of autophagosome assembly|
|Rab guanyl-nucleotide exchange factor activity|
|regulation of vacuole organization|
|enzyme activator activity|
|positive regulation of macroautophagy|
|positive regulation of organelle assembly|
|establishment of protein localization to endoplasmic reticulum|
|positive regulation of autophagy|
|protein localization to endoplasmic reticulum|
|Rab GTPase binding|
|regulation of macroautophagy|
|regulation of organelle assembly|
|establishment of protein localization to membrane|
|GTPase activator activity|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|positive regulation of GTPase activity|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|protein localization to membrane|
|regulation of GTPase activity|
|protein heterodimerization activity|
|positive regulation of cellular component biogenesis|
|protein-containing complex|
|positive regulation of organelle organization|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|intracellular protein transport|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-4.27|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-4.12|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.09|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.74|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.71|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.73|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.74|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB3GAP2 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>