RAB9B [The Human Chemical-Genetic Interaction Map Project]

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======= RAB9B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB9B
  * **<color #00a2e8>Official Name</color>**: RAB9B, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51209|51209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP90|Q9NP90]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB9B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB9B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the transport of proteins between the endosomes and the trans Golgi network. {ECO:0000250|UniProtKB:P24408}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagocytic vesicle|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|GDP binding|
|retrograde transport, endosome to Golgi|
|secretory granule membrane|
|cytosolic transport|
|endosomal transport|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|GTPase activity|
|GTP binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.92|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.89|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.86|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.91|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18095
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB9B Expression in NALM6 Cells: -2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>