RABGGTB [The Human Chemical-Genetic Interaction Map Project]

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======= RABGGTB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RABGGTB
  * **<color #00a2e8>Official Name</color>**: Rab geranylgeranyltransferase subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5876|5876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53611|P53611]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RABGGTB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RABGGTB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prenyltrans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rab geranylgeranyltransferase activity|
|Rab-protein geranylgeranyltransferase complex|
|protein geranylgeranylation|
|prenylation|
|protein prenylation|
|Rab GTPase binding|
|visual perception|
|sensory perception of light stimulus|
|post-translational protein modification|
|zinc ion binding|
|sensory perception|
|nervous system process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.51|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.48|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.43|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.42|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.33|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.32|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.25|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.08|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.08|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.04|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.96|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.96|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.96|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.9|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.9|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.89|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.89|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.88|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.87|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.85|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.85|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.84|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.84|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.82|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.76|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.74|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.72|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.71|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.71|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.7|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.7|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.05|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.13|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.34|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.602|
|[[:human genes:g:gemin6|GEMIN6]]|0.59|
|[[:human genes:s:srp14|SRP14]]|0.57|
|[[:human genes:g:ggps1|GGPS1]]|0.547|
|[[:human genes:t:thg1l|THG1L]]|0.546|
|[[:human genes:p:ptar1|PTAR1]]|0.543|
|[[:human genes:a:alg1|ALG1]]|0.527|
|[[:human genes:a:atxn10|ATXN10]]|0.521|
|[[:human genes:r:rtcb|RTCB]]|0.519|
|[[:human genes:p:ppp6c|PPP6C]]|0.517|
|[[:human genes:h:hars|HARS]]|0.517|
|[[:human genes:t:ten1|TEN1]]|0.515|
|[[:human genes:u:uap1|UAP1]]|0.513|
|[[:human genes:r:rpp21|RPP21]]|0.511|
|[[:human genes:v:vezt|VEZT]]|0.509|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.507|
|[[:human genes:d:dpagt1|DPAGT1]]|0.507|
|[[:human genes:c:c15orf41|C15orf41]]|0.506|
|[[:human genes:d:dhrsx|DHRSX]]|0.504|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.502|
|[[:human genes:p:ppcs|PPCS]]|0.501|
|[[:human genes:f:fh|FH]]|0.499|
|[[:human genes:n:nsmce1|NSMCE1]]|0.496|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.494|
|[[:human genes:t:tsen54|TSEN54]]|0.494|
|[[:human genes:g:gmppb|GMPPB]]|0.488|
|[[:human genes:e:exoc4|EXOC4]]|0.488|
|[[:human genes:g:gemin7|GEMIN7]]|0.488|
|[[:human genes:a:adsl|ADSL]]|0.487|
|[[:human genes:r:rpia|RPIA]]|0.482|
|[[:human genes:p:pmm2|PMM2]]|0.475|
|[[:human genes:s:snapc5|SNAPC5]]|0.474|
|[[:human genes:t:tprkb|TPRKB]]|0.473|
|[[:human genes:p:ppp4c|PPP4C]]|0.472|
|[[:human genes:d:ddx20|DDX20]]|0.471|
|[[:human genes:n:nae1|NAE1]]|0.47|
|[[:human genes:r:rft1|RFT1]]|0.469|
|[[:human genes:d:dolk|DOLK]]|0.466|
|[[:human genes:c:c11orf57|C11orf57]]|0.461|
|[[:human genes:a:atic|ATIC]]|0.458|
|[[:human genes:t:trmt5|TRMT5]]|0.457|
|[[:human genes:r:rpe|RPE]]|0.452|
|[[:human genes:p:ppcdc|PPCDC]]|0.452|
|[[:human genes:p:pgk1|PGK1]]|0.452|
|[[:human genes:t:triap1|TRIAP1]]|0.451|
|[[:human genes:c:cxorf56|CXorf56]]|0.45|
|[[:human genes:c:chchd4|CHCHD4]]|0.45|
|[[:human genes:t:ttc4|TTC4]]|0.448|
|[[:human genes:t:tubd1|TUBD1]]|0.448|
|[[:human genes:v:vma21|VMA21]]|0.448|
|[[:human genes:f:fen1|FEN1]]|0.446|
|[[:human genes:e:elp3|ELP3]]|0.444|
|[[:human genes:z:zcrb1|ZCRB1]]|0.444|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.444|
|[[:human genes:c:ccdc115|CCDC115]]|0.443|
|[[:human genes:s:srd5a3|SRD5A3]]|0.442|
|[[:human genes:t:tbcb|TBCB]]|0.442|
|[[:human genes:r:rad50|RAD50]]|0.442|
|[[:human genes:t:tpi1|TPI1]]|0.441|
|[[:human genes:g:gfpt1|GFPT1]]|0.439|
|[[:human genes:c:ctc1|CTC1]]|0.439|
|[[:human genes:z:zrsr2|ZRSR2]]|0.439|
|[[:human genes:k:kdm8|KDM8]]|0.439|
|[[:human genes:c:cdipt|CDIPT]]|0.438|
|[[:human genes:d:dr1|DR1]]|0.435|
|[[:human genes:u:utp23|UTP23]]|0.435|
|[[:human genes:p:pgm3|PGM3]]|0.434|
|[[:human genes:z:znhit1|ZNHIT1]]|0.433|
|[[:human genes:c:cep57|CEP57]]|0.432|
|[[:human genes:h:hspd1|HSPD1]]|0.431|
|[[:human genes:e:eprs|EPRS]]|0.431|
|[[:human genes:s:spr|SPR]]|0.43|
|[[:human genes:d:ddx39a|DDX39A]]|0.426|
|[[:human genes:r:rfk|RFK]]|0.426|
|[[:human genes:w:wdr92|WDR92]]|0.426|
|[[:human genes:g:gemin5|GEMIN5]]|0.426|
|[[:human genes:p:psmg2|PSMG2]]|0.424|
|[[:human genes:e:exoc3|EXOC3]]|0.424|
|[[:human genes:u:ube2m|UBE2M]]|0.422|
|[[:human genes:d:dhps|DHPS]]|0.422|
|[[:human genes:u:uba3|UBA3]]|0.422|
|[[:human genes:x:xrcc2|XRCC2]]|0.421|
|[[:human genes:r:rad1|RAD1]]|0.42|
|[[:human genes:d:ddx55|DDX55]]|0.418|
|[[:human genes:s:slc25a26|SLC25A26]]|0.418|
|[[:human genes:m:mettl14|METTL14]]|0.418|
|[[:human genes:l:lsm10|LSM10]]|0.416|
|[[:human genes:o:osgep|OSGEP]]|0.415|
|[[:human genes:c:c14orf166|C14orf166]]|0.415|
|[[:human genes:n:n6amt1|N6AMT1]]|0.415|
|[[:human genes:t:trappc3|TRAPPC3]]|0.414|
|[[:human genes:r:rbm14|RBM14]]|0.412|
|[[:human genes:n:nbn|NBN]]|0.412|
|[[:human genes:d:dnlz|DNLZ]]|0.409|
|[[:human genes:t:tkt|TKT]]|0.409|
|[[:human genes:e:elp2|ELP2]]|0.404|
|[[:human genes:b:bub3|BUB3]]|0.403|
|[[:human genes:e:eno1|ENO1]]|0.403|
|[[:human genes:e:elp6|ELP6]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 724/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 103
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RABGGTB Expression in NALM6 Cells: 8.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>