RABIF [The Human Chemical-Genetic Interaction Map Project]

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======= RABIF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RABIF
  * **<color #00a2e8>Official Name</color>**: RAB interacting factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5877|5877]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47224|P47224]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RABIF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RABIF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603417|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mss4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-Golgi vesicle-mediated transport|
|guanyl-nucleotide exchange factor activity|
|membrane fusion|
|small GTPase mediated signal transduction|
|Golgi vesicle transport|
|zinc ion binding|
|membrane organization|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|intracellular signal transduction|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2.64|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.41|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.13|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.94|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.77|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.7|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.7|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.79|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.79|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.82|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.86|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.89|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.96|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.07|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.15|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.66|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.71|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.77|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.03|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|3.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab10|RAB10]]|0.554|
|[[:human genes:d:dennd4a|DENND4A]]|0.496|
|[[:human genes:d:dohh|DOHH]]|0.468|
|[[:human genes:p:pdpk1|PDPK1]]|0.435|
|[[:human genes:c:cmtm6|CMTM6]]|0.418|
|[[:human genes:e:exoc2|EXOC2]]|0.414|
|[[:human genes:e:exoc5|EXOC5]]|0.413|
|[[:human genes:r:romo1|ROMO1]]|0.412|
|[[:human genes:t:taz|TAZ]]|0.409|
|[[:human genes:t:thg1l|THG1L]]|0.405|
|[[:human genes:r:rnmt|RNMT]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 59/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|5/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|7/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4775
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RABIF Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>