RAC3 [The Human Chemical-Genetic Interaction Map Project]

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======= RAC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAC3
  * **<color #00a2e8>Official Name</color>**: Rac family small GTPase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5881|5881]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60763|P60763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebral cortex GABAergic interneuron development|
|regulation of neuron maturation|
|cerebral cortex GABAergic interneuron differentiation|
|engulfment of apoptotic cell|
|GABAergic neuron differentiation|
|synaptic transmission, GABAergic|
|positive regulation of cell adhesion mediated by integrin|
|regulation of cell maturation|
|cerebral cortex neuron differentiation|
|homeostasis of number of cells within a tissue|
|forebrain neuron development|
|filamentous actin|
|positive regulation of substrate adhesion-dependent cell spreading|
|cell periphery|
|apoptotic cell clearance|
|regulation of cell adhesion mediated by integrin|
|forebrain neuron differentiation|
|neuromuscular process controlling balance|
|regulation of substrate adhesion-dependent cell spreading|
|calcium-dependent protein binding|
|actin cytoskeleton reorganization|
|forebrain generation of neurons|
|endomembrane system|
|Rho protein signal transduction|
|central nervous system neuron development|
|positive regulation of actin filament polymerization|
|cell projection|
|neuromuscular process|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein polymerization|
|growth cone|
|phagocytosis, engulfment|
|plasma membrane invagination|
|membrane invagination|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of actin filament polymerization|
|central nervous system neuron differentiation|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|tissue homeostasis|
|positive regulation of supramolecular fiber organization|
|homeostasis of number of cells|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|neuron projection|
|multicellular organismal homeostasis|
|phagocytosis|
|GTPase activity|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|neuronal cell body|
|regulation of cellular component size|
|forebrain development|
|regulation of actin filament-based process|
|GTP binding|
|positive regulation of cell adhesion|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|synaptic signaling|
|protein kinase binding|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|endocytosis|
|actin filament-based process|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|neuron projection development|
|import into cell|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5361
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAC3 Expression in NALM6 Cells: 1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>