RACGAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RACGAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RACGAP1
  * **<color #00a2e8>Official Name</color>**: Rac GTPase activating protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29127|29127]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0H5|Q9H0H5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RACGAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RACGAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|RhoGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centralspindlin complex|
|assembly of actomyosin apparatus involved in cytokinesis|
|actomyosin contractile ring assembly|
|actomyosin contractile ring organization|
|mitotic spindle midzone assembly|
|mitotic spindle elongation|
|spindle elongation|
|spindle midzone assembly|
|regulation of attachment of spindle microtubules to kinetochore|
|sulfate transport|
|spindle midzone|
|gamma-tubulin binding|
|Flemming body|
|neuroblast proliferation|
|cytokinetic process|
|mitotic spindle assembly|
|beta-tubulin binding|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|alpha-tubulin binding|
|positive regulation of cytokinesis|
|cortical actin cytoskeleton organization|
|sulfur compound transport|
|cortical cytoskeleton organization|
|stem cell proliferation|
|cleavage furrow|
|extrinsic component of cytoplasmic side of plasma membrane|
|mitotic cytokinesis|
|neural precursor cell proliferation|
|mitotic spindle organization|
|mitotic spindle|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|positive regulation of cell division|
|acrosomal vesicle|
|regulation of cytokinesis|
|cytoskeleton-dependent cytokinesis|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|cytokinesis|
|antigen processing and presentation of peptide antigen via MHC class II|
|spindle assembly|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|actomyosin structure organization|
|regulation of embryonic development|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|midbody|
|inorganic anion transport|
|regulation of cell division|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|nuclear chromosome segregation|
|microtubule binding|
|microtubule-based movement|
|chromosome segregation|
|GTPase activator activity|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|microtubule|
|regulation of small GTPase mediated signal transduction|
|Golgi vesicle transport|
|positive regulation of cell cycle|
|positive regulation of GTPase activity|
|protein kinase binding|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|cell division|
|actin cytoskeleton organization|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|actin filament-based process|
|anion transport|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|regulation of cell cycle process|
|organelle assembly|
|positive regulation of hydrolase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of hydrolase activity|
|cell cycle|
|ion transport|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.16|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.05|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.97|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.96|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.89|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.84|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.74|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.71|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.71|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.77|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.07|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.12|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.23|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.23|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 730/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1051
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RACGAP1 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>