RAD51 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RAD51 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD51
  * **<color #00a2e8>Official Name</color>**: RAD51 recombinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5888|5888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06609|Q06609]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD51&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD51|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179617|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028). {ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308, ECO:0000269|PubMed:28575658}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RecA|
|Rad51|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic recombination-dependent replication fork processing|
|mitotic DNA replication maintenance of fidelity|
|cell cycle DNA replication maintenance of fidelity|
|recombinase activity|
|cellular response to camptothecin|
|strand invasion|
|DNA repair complex assembly|
|DNA recombinase assembly|
|positive regulation of DNA ligation|
|response to camptothecin|
|regulation of DNA ligation|
|double-strand break repair via synthesis-dependent strand annealing|
|mitotic DNA replication|
|telomere maintenance via recombination|
|lateral element|
|DNA unwinding involved in DNA replication|
|mitotic recombination|
|single-stranded DNA helicase activity|
|DNA polymerase binding|
|condensed chromosome|
|nuclear chromosome|
|telomere maintenance via telomere lengthening|
|condensed nuclear chromosome|
|replication fork processing|
|cellular response to alkaloid|
|negative regulation of G0 to G1 transition|
|DNA-dependent DNA replication maintenance of fidelity|
|regulation of G0 to G1 transition|
|DNA-dependent ATPase activity|
|nuclear DNA replication|
|cell cycle DNA replication|
|regulation of double-strand break repair via homologous recombination|
|reciprocal meiotic recombination|
|interstrand cross-link repair|
|homologous recombination|
|site of double-strand break|
|chromosome organization involved in meiotic cell cycle|
|cellular response to ionizing radiation|
|regulation of double-strand break repair|
|cellular response to alcohol|
|response to antineoplastic agent|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|PML body|
|telomere organization|
|double-stranded DNA binding|
|regulation of DNA recombination|
|single-stranded DNA binding|
|meiosis I|
|nuclear chromosome, telomeric region|
|DNA duplex unwinding|
|response to alkaloid|
|meiosis I cell cycle process|
|chromatin|
|DNA geometric change|
|DNA-dependent DNA replication|
|regulation of DNA repair|
|response to ionizing radiation|
|meiotic nuclear division|
|microtubule organizing center|
|meiotic cell cycle process|
|cellular response to radiation|
|double-strand break repair|
|protein C-terminus binding|
|positive regulation of DNA metabolic process|
|protein-DNA complex assembly|
|DNA replication|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|meiotic cell cycle|
|response to alcohol|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|nuclear division|
|DNA conformation change|
|organelle fission|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|negative regulation of cell cycle process|
|protein homooligomerization|
|anatomical structure homeostasis|
|enzyme binding|
|regulation of DNA metabolic process|
|mitochondrial matrix|
|chromatin binding|
|cellular response to drug|
|response to radiation|
|DNA repair|
|protein complex oligomerization|
|cellular response to organic cyclic compound|
|negative regulation of cell cycle|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|nucleolus|
|response to organic cyclic compound|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|chromosome organization|
|identical protein binding|
|response to nitrogen compound|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|mitochondrion|
|cell cycle|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.05|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.86|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.75|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.78|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.81|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.91|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.39|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.49|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.55|
|[[:human genes:r:rpl35|RPL35]]|0.549|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.544|
|[[:human genes:s:slc4a1|SLC4A1]]|0.543|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.537|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.532|
|[[:human genes:a:acsf2|ACSF2]]|0.525|
|[[:human genes:p:polr2j3|POLR2J3]]|0.525|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.524|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.519|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.507|
|[[:human genes:n:narfl|NARFL]]|0.507|
|[[:human genes:h:hivep3|HIVEP3]]|0.502|
|[[:human genes:s:snrpa1|SNRPA1]]|0.501|
|[[:human genes:c:c14orf93|C14orf93]]|0.5|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.5|
|[[:human genes:k:krt78|KRT78]]|0.5|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.5|
|[[:human genes:s:ssh2|SSH2]]|0.498|
|[[:human genes:z:zfand5|ZFAND5]]|0.492|
|[[:human genes:s:supt5h|SUPT5H]]|0.491|
|[[:human genes:p:pole|POLE]]|0.491|
|[[:human genes:n:npipb8|NPIPB8]]|0.488|
|[[:human genes:p:psmb4|PSMB4]]|0.488|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.487|
|[[:human genes:c:ccna2|CCNA2]]|0.486|
|[[:human genes:o:orc1|ORC1]]|0.486|
|[[:human genes:p:psma6|PSMA6]]|0.486|
|[[:human genes:r:riok2|RIOK2]]|0.485|
|[[:human genes:s:supt6h|SUPT6H]]|0.484|
|[[:human genes:c:copz1|COPZ1]]|0.483|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.483|
|[[:human genes:s:sec13|SEC13]]|0.482|
|[[:human genes:a:aqr|AQR]]|0.482|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.482|
|[[:human genes:d:dtl|DTL]]|0.482|
|[[:human genes:o:orc6|ORC6]]|0.48|
|[[:human genes:c:chaf1a|CHAF1A]]|0.48|
|[[:human genes:p:pwp2|PWP2]]|0.479|
|[[:human genes:c:cbwd5|CBWD5]]|0.479|
|[[:human genes:c:chd4|CHD4]]|0.475|
|[[:human genes:h:hap1|HAP1]]|0.474|
|[[:human genes:o:osbp|OSBP]]|0.473|
|[[:human genes:g:golga8o|GOLGA8O]]|0.472|
|[[:human genes:v:vasn|VASN]]|0.472|
|[[:human genes:t:timeless|TIMELESS]]|0.472|
|[[:human genes:f:fcn2|FCN2]]|0.471|
|[[:human genes:c:cactin|CACTIN]]|0.471|
|[[:human genes:g:golga6a|GOLGA6A]]|0.469|
|[[:human genes:d:disp2|DISP2]]|0.469|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.468|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.468|
|[[:human genes:m:mt1e|MT1E]]|0.467|
|[[:human genes:i:ik|IK]]|0.467|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.467|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.467|
|[[:human genes:n:nop16|NOP16]]|0.467|
|[[:human genes:e:exosc8|EXOSC8]]|0.467|
|[[:human genes:p:ppm1d|PPM1D]]|0.467|
|[[:human genes:t:ticrr|TICRR]]|0.466|
|[[:human genes:c:cbwd3|CBWD3]]|0.466|
|[[:human genes:u:upf1|UPF1]]|0.464|
|[[:human genes:d:dido1|DIDO1]]|0.464|
|[[:human genes:e:exosc9|EXOSC9]]|0.463|
|[[:human genes:p:psmd7|PSMD7]]|0.463|
|[[:human genes:r:rpl6|RPL6]]|0.463|
|[[:human genes:p:psmc2|PSMC2]]|0.463|
|[[:human genes:c:cdc6|CDC6]]|0.462|
|[[:human genes:r:rps2|RPS2]]|0.462|
|[[:human genes:f:fbxw9|FBXW9]]|0.462|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.462|
|[[:human genes:n:nup160|NUP160]]|0.461|
|[[:human genes:p:psmd2|PSMD2]]|0.458|
|[[:human genes:t:tspy1|TSPY1]]|0.457|
|[[:human genes:u:uqcrh|UQCRH]]|0.457|
|[[:human genes:n:npipb5|NPIPB5]]|0.456|
|[[:human genes:n:nol12|NOL12]]|0.456|
|[[:human genes:e:exosc5|EXOSC5]]|0.455|
|[[:human genes:p:pcf11|PCF11]]|0.453|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.453|
|[[:human genes:s:smg7|SMG7]]|0.453|
|[[:human genes:c:ccdc94|CCDC94]]|0.453|
|[[:human genes:c:cdc45|CDC45]]|0.453|
|[[:human genes:r:rpl30|RPL30]]|0.452|
|[[:human genes:m:myo1h|MYO1H]]|0.452|
|[[:human genes:r:rrn3|RRN3]]|0.452|
|[[:human genes:p:polr2d|POLR2D]]|0.452|
|[[:human genes:c:copb1|COPB1]]|0.451|
|[[:human genes:s:sf3a1|SF3A1]]|0.451|
|[[:human genes:s:slc6a17|SLC6A17]]|0.45|
|[[:human genes:h:hinfp|HINFP]]|0.448|
|[[:human genes:r:rpl34|RPL34]]|0.448|
|[[:human genes:d:ddx56|DDX56]]|0.447|
|[[:human genes:c:cbwd6|CBWD6]]|0.446|
|[[:human genes:w:wdr43|WDR43]]|0.446|
|[[:human genes:p:pola2|POLA2]]|0.446|
|[[:human genes:s:sart1|SART1]]|0.444|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.444|
|[[:human genes:t:tfip11|TFIP11]]|0.444|
|[[:human genes:i:igfn1|IGFN1]]|0.443|
|[[:human genes:r:rrp15|RRP15]]|0.442|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.442|
|[[:human genes:p:pan3|PAN3]]|0.442|
|[[:human genes:t:traip|TRAIP]]|0.441|
|[[:human genes:n:nupl1|NUPL1]]|0.441|
|[[:human genes:a:aamp|AAMP]]|0.441|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.441|
|[[:human genes:r:rrp7a|RRP7A]]|0.44|
|[[:human genes:s:syt9|SYT9]]|0.439|
|[[:human genes:p:psma7|PSMA7]]|0.439|
|[[:human genes:l:loc643669|LOC643669]]|0.439|
|[[:human genes:z:znf655|ZNF655]]|0.438|
|[[:human genes:r:rps9|RPS9]]|0.438|
|[[:human genes:r:rps7|RPS7]]|0.438|
|[[:human genes:p:prpf8|PRPF8]]|0.438|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.437|
|[[:human genes:l:lrr1|LRR1]]|0.437|
|[[:human genes:n:nup43|NUP43]]|0.437|
|[[:human genes:r:ranbp2|RANBP2]]|0.437|
|[[:human genes:p:psmb1|PSMB1]]|0.437|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.436|
|[[:human genes:s:s1pr4|S1PR4]]|0.435|
|[[:human genes:p:psmc1|PSMC1]]|0.434|
|[[:human genes:c:cdh24|CDH24]]|0.434|
|[[:human genes:m:myh2|MYH2]]|0.433|
|[[:human genes:m:myt1l|MYT1L]]|0.433|
|[[:human genes:m:mdm2|MDM2]]|0.432|
|[[:human genes:n:napa|NAPA]]|0.432|
|[[:human genes:c:ctage4|CTAGE4]]|0.432|
|[[:human genes:k:krt5|KRT5]]|0.429|
|[[:human genes:z:znf106|ZNF106]]|0.429|
|[[:human genes:o:ogfr|OGFR]]|0.429|
|[[:human genes:p:psmd3|PSMD3]]|0.429|
|[[:human genes:c:copb2|COPB2]]|0.427|
|[[:human genes:s:sema6b|SEMA6B]]|0.426|
|[[:human genes:g:golga8j|GOLGA8J]]|0.425|
|[[:human genes:a:ankle1|ANKLE1]]|0.425|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.424|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.424|
|[[:human genes:a:aatf|AATF]]|0.424|
|[[:human genes:g:golga6b|GOLGA6B]]|0.423|
|[[:human genes:p:polr2f|POLR2F]]|0.423|
|[[:human genes:c:col2a1|COL2A1]]|0.423|
|[[:human genes:t:tspy8|TSPY8]]|0.422|
|[[:human genes:d:dnm2|DNM2]]|0.422|
|[[:human genes:f:fam25b|FAM25B]]|0.421|
|[[:human genes:f:fam160a1|FAM160A1]]|0.42|
|[[:human genes:p:psmd1|PSMD1]]|0.419|
|[[:human genes:n:nup205|NUP205]]|0.419|
|[[:human genes:p:pola1|POLA1]]|0.419|
|[[:human genes:w:wdr75|WDR75]]|0.418|
|[[:human genes:t:twistnb|TWISTNB]]|0.418|
|[[:human genes:p:pbxip1|PBXIP1]]|0.418|
|[[:human genes:a:ankle2|ANKLE2]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:p:psmb3|PSMB3]]|0.417|
|[[:human genes:c:cgb2|CGB2]]|0.416|
|[[:human genes:c:cdc73|CDC73]]|0.415|
|[[:human genes:n:nol10|NOL10]]|0.413|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.413|
|[[:human genes:c:ccdc116|CCDC116]]|0.413|
|[[:human genes:p:plk1|PLK1]]|0.412|
|[[:human genes:r:rad21|RAD21]]|0.412|
|[[:human genes:r:rpl14|RPL14]]|0.412|
|[[:human genes:p:psmb2|PSMB2]]|0.411|
|[[:human genes:r:rpsa|RPSA]]|0.411|
|[[:human genes:s:slc38a7|SLC38A7]]|0.411|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.41|
|[[:human genes:d:ddx47|DDX47]]|0.41|
|[[:human genes:c:ctr9|CTR9]]|0.41|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:v:vps54|VPS54]]|0.409|
|[[:human genes:c:cope|COPE]]|0.409|
|[[:human genes:s:stil|STIL]]|0.409|
|[[:human genes:n:nup85|NUP85]]|0.408|
|[[:human genes:f:fam86b2|FAM86B2]]|0.407|
|[[:human genes:u:utp3|UTP3]]|0.407|
|[[:human genes:n:nkap|NKAP]]|0.406|
|[[:human genes:m:mms22l|MMS22L]]|0.406|
|[[:human genes:t:trappc11|TRAPPC11]]|0.405|
|[[:human genes:r:rps20|RPS20]]|0.405|
|[[:human genes:n:nsf|NSF]]|0.405|
|[[:human genes:y:ythdc1|YTHDC1]]|0.405|
|[[:human genes:c:chmp2a|CHMP2A]]|0.405|
|[[:human genes:a:akirin2|AKIRIN2]]|0.404|
|[[:human genes:r:rnpc3|RNPC3]]|0.404|
|[[:human genes:r:rrp9|RRP9]]|0.404|
|[[:human genes:d:ddtl|DDTL]]|0.404|
|[[:human genes:n:nbpf10|NBPF10]]|0.403|
|[[:human genes:u:usp17l12|USP17L12]]|0.403|
|[[:human genes:w:wdr46|WDR46]]|0.402|
|[[:human genes:a:ahctf1|AHCTF1]]|0.402|
|[[:human genes:a:arcn1|ARCN1]]|0.402|
|[[:human genes:m:med29|MED29]]|0.401|
|[[:human genes:m:myh7b|MYH7B]]|0.401|
|[[:human genes:p:polr2a|POLR2A]]|0.401|
|[[:human genes:n:nipbl|NIPBL]]|0.401|
|[[:human genes:s:scaf1|SCAF1]]|0.401|
|[[:human genes:u:ubl5|UBL5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 373/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|14/28|
|bone|10/26|
|breast|20/33|
|central nervous system|26/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|6/21|
|liver|9/20|
|lung|34/75|
|lymphocyte|7/16|
|ovary|14/26|
|pancreas|16/24|
|peripheral nervous system|9/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|19/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD51 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>