RAD51C [The Human Chemical-Genetic Interaction Map Project]

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======= RAD51C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD51C
  * **<color #00a2e8>Official Name</color>**: RAD51 paralog C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5889|5889]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43502|O43502]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD51C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD51C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:16215984, ECO:0000269|PubMed:16395335, ECO:0000269|PubMed:19451272, ECO:0000269|PubMed:19783859, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad51|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|female meiosis sister chromatid cohesion|
|Rad51C-XRCC3 complex|
|Rad51B-Rad51C-Rad51D-XRCC2 complex|
|Holliday junction resolvase complex|
|meiotic sister chromatid cohesion|
|meiotic sister chromatid segregation|
|crossover junction endodeoxyribonuclease activity|
|meiosis II cell cycle process|
|meiosis II|
|telomere maintenance via recombination|
|four-way junction DNA binding|
|mitotic recombination|
|male meiosis I|
|replication fork|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|female meiotic nuclear division|
|DNA-dependent ATPase activity|
|male meiotic nuclear division|
|sister chromatid cohesion|
|reciprocal meiotic recombination|
|homologous recombination|
|chromosome organization involved in meiotic cell cycle|
|positive regulation of mitotic cell cycle phase transition|
|meiotic chromosome segregation|
|positive regulation of cell cycle phase transition|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|telomere organization|
|meiosis I|
|meiosis I cell cycle process|
|female gamete generation|
|sister chromatid segregation|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|meiotic cell cycle process|
|double-strand break repair|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|blood coagulation|
|coagulation|
|hemostasis|
|organelle fission|
|anatomical structure homeostasis|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|wound healing|
|regulation of body fluid levels|
|DNA repair|
|spermatogenesis|
|cell junction|
|male gamete generation|
|response to wounding|
|regulation of mitotic cell cycle|
|intracellular membrane-bounded organelle|
|gamete generation|
|perinuclear region of cytoplasm|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|mitochondrion|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|ATP binding|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.02|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.88|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.84|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:ssh2|SSH2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 62/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|2/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|4/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1005
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD51C Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>