RAD54L2 [The Human Chemical-Genetic Interaction Map Project]

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======= RAD54L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD54L2
  * **<color #00a2e8>Official Name</color>**: RAD54 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23132|23132]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4B4|Q9Y4B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD54L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD54L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620006|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|SNF2 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA helicase activity|
|DNA duplex unwinding|
|DNA geometric change|
|DNA conformation change|
|chromosome organization|
|DNA binding|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-3.91|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.86|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.47|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.2|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.9|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.88|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.87|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD54L2 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>