RALGAPB [The Human Chemical-Genetic Interaction Map Project]

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======= RALGAPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RALGAPB
  * **<color #00a2e8>Official Name</color>**: Ral GTPase activating protein non-catalytic subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57148|57148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86X10|Q86X10]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RALGAPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RALGAPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618833|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of GTPase activity|
|GTPase activator activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|protein heterodimerization activity|
|positive regulation of hydrolase activity|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-3.62|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.54|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.45|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-3.38|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.24|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.9|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.68|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.36|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.34|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.17|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.05|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.01|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.93|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.9|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.9|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.89|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.87|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.84|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.77|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.71|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.71|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.72|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.81|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.84|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.91|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.03|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.09|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.14|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.15|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.17|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.22|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.28|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.29|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.32|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.32|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.39|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.51|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.63|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.82|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.89|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scap|SCAP]]|0.505|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.425|
|[[:human genes:h:htt|HTT]]|0.422|
|[[:human genes:a:actr2|ACTR2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5276
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RALGAPB Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>